Yu Xiaolong, Chen Kehao, Wang Qi, Zhang Wenjing, Zhu Jin
Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210093, P. R. China.
Chem Commun (Camb). 2018 Jan 31;54(10):1197-1200. doi: 10.1039/c7cc08611c.
An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.
本文描述了通过钴（III）催化高效合成2,5-二取代恶唑的方法。该合成在温和条件下通过N-新戊酰氧基酰胺与炔烃的[3+2]环加成反应实现。该反应通过内部氧化途径进行，底物范围非常广泛。通过该方案已证明了天然产物如特沙明和巴索辛的一步合成。
