Mohammadi Ziarani Ghodsi, Mofatehnia Parisa, Mohajer Fatemeh, Badiei Alireza
Department of Chemistry, Faculty of Physics and Chemistry, University of Alzahra Tehran Iran
School of Chemistry, College of Science, University of Tehran Tehran Iran.
RSC Adv. 2020 Aug 14;10(50):30094-30109. doi: 10.1039/d0ra03611k. eCollection 2020 Aug 10.
Yolk-shell nanoparticles (YSNPs) are a new class of hollow nanostructures, and their unique properties can be utilized in drug delivery systems. The recent progress in YSNPs-based carriers is highlighted in drug delivery systems. Doxorubicin hydrochloride, ceftriaxone sodium, and methotrexate are three of the most common drugs that are used in this field. According to the reported studies, the materials used most often as yolk-shells are magnetic nanoparticles and polymers. The used methods for synthesizing a diverse array of YSNPs are classified based on their core structures. Various properties of YSNPs include their high drug-loading capacity, and their ability to decrease drug toxicity and satisfactorily and efficiently release drugs.
蛋黄壳纳米颗粒（YSNPs）是一类新型的中空纳米结构，其独特性能可用于药物递送系统。基于YSNPs的载体在药物递送系统中的最新进展得到了重点介绍。盐酸多柔比星、头孢曲松钠和甲氨蝶呤是该领域最常用的三种药物。根据已报道的研究，最常被用作蛋黄壳的材料是磁性纳米颗粒和聚合物。合成各种YSNPs所采用的方法根据其核心结构进行分类。YSNPs的各种特性包括其高载药能力、降低药物毒性的能力以及令人满意且高效地释放药物的能力。
