Zhang Yunsha, Lian Lu, Fu Rong, Liu Jueling, Shan Xiaoqian, Jin Yang, Xu Shixin
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine Tianjin, China.
Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin, China.
Front Cell Neurosci. 2022 Apr 18;16:889442. doi: 10.3389/fncel.2022.889442. eCollection 2022.
Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control.
小胶质细胞与其他细胞之间的通讯最近一直处于中枢神经系统（CNS）疾病研究的前沿。在本综述中，我们概述了小胶质细胞介导的神经炎症，重点介绍了在缺血性中风（IS）背景下小胶质细胞与中枢神经系统常驻细胞和浸润细胞之间串扰的最新研究，并讨论了这些相互作用如何影响缺血性中风的病程。对小胶质细胞-细胞间通讯的深入探索将有助于开发治疗工具并将其临床转化以控制中风。
