Graduate College of Youjiang Medical University for Nationalities, Baise, China.
Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Front Endocrinol (Lausanne). 2022 May 16;13:883862. doi: 10.3389/fendo.2022.883862. eCollection 2022.
Previous studies have shown that obesity has a positive effect on bone mineral density (BMD). However, excessive obesity is harmful to health, especially in older adults. In addition, it is unclear what body mass index (BMI) and waist circumference (WC) to maintain for the most beneficial BMD in older adults.
Multivariate logistic regression models were used to investigate the association between BMI, WC, and femoral neck BMD using the most recent data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Fitting smoothing curves and saturation effects analysis were also used to determine the association of nonlinear relationships between BMI, WC, and femoral neck BMD.
The analysis included a total of 2,903 adults. We discovered that BMD and WC were positively linked to femoral neck BMD. The favorable associations of BMI and WC with femoral neck BMD were maintained in all subgroup analyses stratified by sex and race, except among Mexican Americans. Furthermore, smoothing curve fitting revealed that the link between BMI and BMD was not only a linear connection, and that there was a saturation point. The BMI saturation value in the femoral neck BMD was 24.3 (kg/m), according to the saturation effect analysis.
In persons over the age of 50, our research found a positive relationship between obesity and BMD, and we also found a saturation value between BMI and BMD. According to this study, maintaining BMI at a moderate level (about 24.3 kg/m) would result in an optimal balance between BMI and BMD in adults over 50 years of age.
先前的研究表明，肥胖对骨密度（BMD）有积极影响。然而，过度肥胖对健康有害，尤其是对老年人而言。此外，对于老年人来说，维持什么样的体重指数（BMI）和腰围（WC）才能获得最有益的 BMD 尚不清楚。
使用最新的 2017-2020 年全国健康与营养调查（NHANES）数据，多变量逻辑回归模型被用于研究 BMI、WC 与股骨颈 BMD 之间的关联。拟合平滑曲线和饱和效应分析也被用于确定 BMI、WC 与股骨颈 BMD 之间非线性关系的关联。
分析共纳入 2903 名成年人。我们发现 BMD 和 WC 与股骨颈 BMD 呈正相关。除了墨西哥裔美国人之外，在按性别和种族分层的所有亚组分析中，BMI 和 WC 与股骨颈 BMD 的有利关联均得以维持。此外，平滑曲线拟合显示，BMI 与 BMD 之间的联系不仅是线性的，而且存在一个饱和点。根据饱和效应分析，BMI 在股骨颈 BMD 中的饱和值为 24.3（kg/m）。
在 50 岁以上的人群中，我们的研究发现肥胖与 BMD 之间存在正相关，并且我们还发现 BMI 与 BMD 之间存在一个饱和值。根据这项研究，维持 BMI 在一个适中的水平（约 24.3kg/m）可能会使 50 岁以上成年人的 BMI 和 BMD 之间达到最佳平衡。
