用于人体双光子视觉研究的飞秒掺铒光纤激光源，波长可在872至1075纳米之间调谐。
Femtosecond Er-doped fiber laser source tunable from 872 to 1075 nm for two-photon vision studies in humans.
作者信息
Stachowiak Dorota, Marzejon Marcin, Bogusławski Jakub, Łaszczych Zbigniew, Komar Katarzyna, Wojtkowski Maciej, Soboń Grzegorz
机构信息
Laser & Fiber Electronics Group, Faculty of Electronics, Photonics and Microsystems, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Department of Physical Chemistry of Biological Systems, Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
出版信息
Biomed Opt Express. 2022 Mar 4;13(4):1899-1911. doi: 10.1364/BOE.452609. eCollection 2022 Apr 1.
We report the development of a widely-tunable femtosecond fiber laser system and its application for two-photon vision studies. The source is based on an Er-doped fiber laser with spectral shift up to 2150 nm, followed by a second harmonic generation module to generate a frequency-doubled beam tunable from 872 to 1075 nm. The source delivers sub-230 fs pulses with nearly-constant duration over the entire tuning range, with output powers between 0.68-1.24 mW, which corresponds to a pulse energy of 13.2-24.1 pJ. Such pulse energy is sufficient for employing a system for measurements of two-photon scotopic spectral sensitivity of two-photon vision in humans. The laser parameters allow for very efficient and safe two-photon stimulation of the human visual system, as proved by a good separation between one- and two-photon thresholds for wavelengths below 950 nm, which we have confirmed for 3 healthy subjects.
我们报告了一种广泛可调谐的飞秒光纤激光系统的开发及其在双光子视觉研究中的应用。该光源基于一个光谱偏移高达2150 nm的掺铒光纤激光器，随后是一个二次谐波产生模块，以产生波长在872至1075 nm之间可调谐的倍频光束。该光源在整个调谐范围内输出持续时间小于230 fs的脉冲，且脉冲持续时间几乎恒定，输出功率在0.68 - 1.24 mW之间，对应脉冲能量为13.2 - 24.1 pJ。这样的脉冲能量足以用于测量人体双光子视觉的双光子暗视光谱灵敏度的系统。激光参数使得对人类视觉系统进行非常高效且安全的双光子刺激成为可能，这一点通过低于950 nm波长下单光子和双光子阈值之间的良好分离得到了证明，我们已对3名健康受试者进行了确认。
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