Salassi Sebastian, Canepa Ester, Ferrando Riccardo, Rossi Giulia
Department of Physics, University of Genoa Via Dodecaneso 33 16146 Genoa Italy
Department of Chemistry and Industrial Chemistry, University of Genoa Via Dodecaneso 31 16146 Genoa Italy.
RSC Adv. 2019 May 7;9(25):13992-13997. doi: 10.1039/c9ra02462j.
Monolayer-protected gold nanoparticles (Au NPs) are promising biomedical tools with applications in diagnosis and therapy, thanks to their biocompatibility and versatility. Here we show how the NP surface functionalization can drive the mechanism of interaction with lipid membranes. In particular, we show that the spontaneous protonation of anionic carboxylic groups on the NP surface can make the NP-membrane interaction faster and less disruptive.
单层保护金纳米颗粒（Au NPs）因其生物相容性和多功能性，是用于诊断和治疗的很有前景的生物医学工具。在此我们展示了纳米颗粒表面功能化如何驱动与脂质膜的相互作用机制。特别是，我们表明纳米颗粒表面阴离子羧基的自质子化可使纳米颗粒与膜的相互作用更快且破坏性更小。
