Zhang Xiu-Juan, Liu Shao-Fang, Lu Yan, Wang Jian-Yue, Chen Kao-Shan
School of Life Science, Shandong University Qingdao 266000 China
Shandong Peanut Research Institute Qingdao Shan Dong China.
RSC Adv. 2019 Apr 9;9(20):11092-11100. doi: 10.1039/c8ra10091h.
A novel burdock fructooligosaccharide (BFO-1) was extracted from fresh burdock roots. In our study, we found that BFO-1 possessed immunoenhancing activity and . The proliferation activities of splenocytes were significantly stimulated at a BFO-1 dose of 1000 μg ml ( < 0.05), peritoneal macrophages showed increased activities of phagocytosis and acid phosphatase and increased production of NO at a BFO-1 dose of 1000 μg ml ( < 0.01) . In normal mice, BFO-1 promoted the activities of peritoneal macrophages at dosages of 250 and 500 mg per kg per day ( < 0.01). Similarly, in immunosuppressed mice, BFO-1 enhanced the activities of peritoneal macrophages at the dosage of 1000 mg per kg per day ( < 0.05). Furthermore, S180 tumor-bearing mice that were pre-administered BFO-1 solution showed improved immunological function and suppressed tumor growth. These data indicate that BFO-1 can improve the functioning of the immune system and has the potential to be developed as a dietary supplement and medicinal food.
一种新型牛蒡低聚果糖（BFO-1）从新鲜牛蒡根中提取。在我们的研究中，我们发现BFO-1具有免疫增强活性。在BFO-1剂量为1000μg/ml时，脾细胞的增殖活性受到显著刺激（P<0.05），在BFO-1剂量为1000μg/ml时，腹腔巨噬细胞的吞噬作用和酸性磷酸酶活性增加，NO产生增加（P<0.01）。在正常小鼠中，BFO-1以每天每千克250和500mg的剂量促进腹腔巨噬细胞的活性（P<0.01）。同样，在免疫抑制小鼠中，BFO-1以每天每千克1000mg的剂量增强腹腔巨噬细胞的活性（P<0.05）。此外，预先给予BFO-1溶液的荷S180肿瘤小鼠显示出免疫功能改善和肿瘤生长受到抑制。这些数据表明，BFO-1可以改善免疫系统的功能，有潜力被开发为膳食补充剂和药用食品。
