Dong Zhenqiang, Yuan Qijuan, Huang Keqing, Xu Wanli, Liu Guiting, Gu Zhipeng
Department of Chemistry and Material Engineering, Quzhou University Quzhou 324000 P. R. China.
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University Guangzhou 510006 P. R. China
RSC Adv. 2019 Jun 5;9(31):17737-17744. doi: 10.1039/c9ra02695a. eCollection 2019 Jun 4.
Gelatin methacryloyl (GelMA)-based biomaterials have been widely used in various biomedical applications due to their suitable biological properties and tuneable physical characteristics. In particular, GelMA can be used as a versatile matrix for bone tissue engineering scaffolds various strategies to overcome major obstacles such as insufficient mechanical property and uncontrollable degradation. This review presents the research status of GelMA, its structure and function, GelMA-based biomaterials and the development of methods along with their existing challenges.
基于甲基丙烯酰化明胶（GelMA）的生物材料因其合适的生物学特性和可调节的物理特性而被广泛应用于各种生物医学领域。特别是，GelMA可作为骨组织工程支架的通用基质，采用各种策略来克服诸如机械性能不足和降解不可控等主要障碍。本文综述了GelMA的研究现状、其结构与功能、基于GelMA的生物材料及其制备方法的发展以及现存的挑战。
