Codrea Cosmin Iulian, Baykara Dilruba, Mitran Raul-Augustin, Koyuncu Ayşe Ceren Çalıkoğlu, Gunduz Oguzhan, Ficai Anton
Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania.
Institute of Physical Chemistry "Ilie Murgulescu" of the Romanian Academy, 060021 Bucharest, Romania.
Polymers (Basel). 2024 Jul 6;16(13):1932. doi: 10.3390/polym16131932.
New gelatin methacryloyl (GelMA)-strontium-doped nanosize hydroxyapatite (SrHA) composite hydrogel scaffolds were developed using UV photo-crosslinking and 3D printing for bone tissue regeneration, with the controlled delivery capacity of strontium (Sr). While Sr is an effective anti-osteoporotic agent with both anti-resorptive and anabolic properties, it has several important side effects when systemic administration is applied. Multi-layer composite scaffolds for bone tissue regeneration were developed based on the digital light processing (DLP) 3D printing technique through the photopolymerization of GelMA. The chemical, morphological, and biocompatibility properties of these scaffolds were investigated. The composite gels were shown to be suitable for 3D printing. In vitro cell culture showed that osteoblasts can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-SrHA hydrogel has good cell viability and biocompatibility. The GelMA-SrHA composites are promising 3D-printed scaffolds for bone repair.
新型甲基丙烯酰化明胶（GelMA）-掺锶纳米羟基磷灰石（SrHA）复合水凝胶支架通过紫外光交联和3D打印技术制备而成，用于骨组织再生，并具有可控的锶（Sr）释放能力。虽然Sr是一种有效的抗骨质疏松剂，具有抗吸收和合成代谢特性，但全身给药时会产生一些重要的副作用。基于数字光处理（DLP）3D打印技术，通过GelMA的光聚合反应，开发了用于骨组织再生的多层复合支架。研究了这些支架的化学、形态和生物相容性。结果表明，复合凝胶适用于3D打印。体外细胞培养显示，成骨细胞能够在水凝胶表面黏附并增殖，这表明GelMA-SrHA水凝胶具有良好的细胞活力和生物相容性。GelMA-SrHA复合材料是用于骨修复的很有前景的3D打印支架。
