一种用于定量检测食品、水和活细胞中铝的高灵敏度和高选择性荧光探针。
A highly sensitive and selective fluorescent probe for quantitative detection of Al in food, water, and living cells.
作者信息
Jiang Qian, Li Mingxin, Song Jie, Yang Yiqin, Xu Xu, Xu Haijun, Wang Shifa
机构信息
Nanjing Forestry University China.
Department of Chemistry and Biochemistry, University of Michigan-Flint USA.
出版信息
RSC Adv. 2019 Apr 3;9(18):10414-10419. doi: 10.1039/c9ra00447e. eCollection 2019 Mar 28.
Three novel β-pinene-based fluorescent probes 2a-2c were designed and synthesized for the selective detection of Al. Probe 2a showed higher fluorescence intensity toward Al than the other two compounds. Probe 2a determined the concentration of Al with a rapid response time (45 s), wide pH range (pH = 1-9), excellent sensitivity (LOD = 8.1 × 10 M) and good selectivity. The recognition mechanism of probe 2a toward Al was confirmed by H NMR, HRMS and DFT analysis. Probe 2a was successfully used as a signal tool to quantitatively detect Al in food samples and environmental water samples. Furthermore, probe 2a was successfully utilized to label intracellular Al, indicating its promising applications in living cells.
设计并合成了三种新型的基于β-蒎烯的荧光探针2a - 2c用于选择性检测铝。探针2a对铝的荧光强度高于其他两种化合物。探针2a测定铝的浓度时响应时间快（45秒）、pH范围宽（pH = 1 - 9）、灵敏度高（检测限 = 8.1×10⁻⁶ M）且选择性好。通过¹H NMR、高分辨质谱（HRMS）和密度泛函理论（DFT）分析证实了探针2a对铝的识别机制。探针2a成功用作信号工具，用于定量检测食品样品和环境水样中的铝。此外，探针2a成功用于标记细胞内的铝，表明其在活细胞中具有广阔的应用前景。
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