Jiang Wei-Long, Han Xiao, Zhang Yu-Feng, Xia Qing-Qing, Zhang Jia-Ming, Wang Feng
Department of Respiration, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine Wuxi City Jiangsu Province 214400 China
Department of Cardiology, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences Shanghai 201800 China
RSC Adv. 2019 Jan 2;9(1):552-559. doi: 10.1039/c8ra07892k. eCollection 2018 Dec 19.
The hallmark features of the development of pulmonary arterial hypertension (PAH) include the proliferation of pulmonary vascular smooth muscle cells, oxidative stress, inflammation, and pulmonary artery remodeling. Arctigenin is a bioactive component of that exerts anti-inflammatory and antiproliferative effects in several diseases; however, its effects on pulmonary arteries are still unclear. This study aimed to investigate the efficacy of arctigenin to prevent PAH. Rats injected with monocrotaline (MCT) progressively developed PAH. Arctigenin treatment (50 mg per kg per day, intra-peritoneally) ameliorated right ventricular systolic pressure and pulmonary arterial remodeling, decreased the expression of inflammatory cytokines, and limited the proliferation of pulmonary vascular smooth muscle cells in lungs. Mechanistically, arctigenin effectively inhibited the MCT-induced elevation of NLRP3, caspase-1, and interleukin 1-beta expression in the lungs. These results indicate that arctigenin ameliorates MCT-induced PAH, at least in part, through exerting its anti-inflammatory, antioxidant, and antiproliferative effects, which inhibit the NLRP3 inflammasome signal pathway in rats.
肺动脉高压（PAH）发展的标志性特征包括肺血管平滑肌细胞增殖、氧化应激、炎症和肺动脉重塑。牛蒡子苷元是牛蒡的一种生物活性成分，在多种疾病中发挥抗炎和抗增殖作用；然而，其对肺动脉的影响仍不清楚。本研究旨在探讨牛蒡子苷元预防PAH的疗效。注射了野百合碱（MCT）的大鼠逐渐发展为PAH。牛蒡子苷元治疗（每天每千克50毫克，腹腔注射）改善了右心室收缩压和肺动脉重塑，降低了炎症细胞因子的表达，并限制了肺中肺血管平滑肌细胞的增殖。从机制上讲，牛蒡子苷元有效抑制了MCT诱导的肺中NLRP3、半胱天冬酶-1和白细胞介素1-β表达的升高。这些结果表明，牛蒡子苷元至少部分地通过发挥其抗炎、抗氧化和抗增殖作用来改善MCT诱导的PAH，这些作用抑制了大鼠的NLRP3炎性小体信号通路。
