Nantes Université, Univ Angers, INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Nantes, France.
Int J Dermatol. 2022 Oct;61(10):1205-1212. doi: 10.1111/ijd.16220. Epub 2022 May 6.
Acne affects more than 640 million people worldwide, including about 85% of adolescents. This inflammatory dermatosis affects the entire population, from teenagers to adults, which reinforces the need to investigate it. Furthermore, in adults, acne has serious consequences, including a psychological impact, low self-esteem, social isolation, and depression. Over the last years, the understanding of acne pathophysiology has improved, mainly thanks to the identification of the pivotal role of the microbiota. The aim of this review was to screen the most recent scientific literature on adult acne and the newly tested treatments. Clinically, therapeutic innovations for the treatment of acne have been recently developed, including pre/probiotics, new molecules, and innovative formulations associated, however, with fewer side effects. Moreover, clinical trials are underway to use off-label molecules that seem to be proving their value in the fight against adult acne.
痤疮影响全球超过 6.4 亿人，包括约 85%的青少年。这种炎症性皮肤病影响着所有人群，从青少年到成年人，这也凸显了对其进行研究的必要性。此外，在成年人中，痤疮会产生严重后果，包括心理影响、自尊心低下、社交孤立和抑郁。近年来，人们对痤疮发病机制的认识有所提高，这主要得益于对微生物群的关键作用的识别。本综述的目的是筛选有关成人痤疮和新测试治疗方法的最新科学文献。在临床上，针对痤疮的治疗创新最近已经得到发展，包括前/益生菌、新分子和与副作用较少相关的创新制剂。此外，正在进行临床试验以使用似乎在对抗成人痤疮方面证明其价值的非适应证分子。
