Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
Department of Medical Sciences, University of Trieste, Trieste, Italy.
Diabetes Care. 2022 Jun 2;45(6):1486-1488. doi: 10.2337/dc21-2643.
To find a carbohydrate (CHO) tolerance threshold for unannounced snacks to avoid the 2 h increase in glycemia (difference between pre- and postmeal blood glucose [ΔBG]) ≥50 mg/dL in advanced hybrid closed-loop (a-HCL) users.
Fourteen children and adolescents with type 1 diabetes (7 females; mean age [± SD] 14.5 ± 3.6 years), users of the Medtronic MiniMed 780G, participated in the study. For 12 days, they did not perform insulin bolus before breakfasts, with defined different quantities and types of CHO, with or without fats, performing blood glucose (BG) before and 2 h after the meal.
A cutoff of 19.8 g of total CHO was found to determine a ΔBG of 50 mg/dL. BG never exceeded 250 mg/dL. Mean time in range was ≥70% in the 2 h following each snack.
Unannounced snacks of up to 20 g of CHO can avoid ΔBG ≥50 mg/dL in MiniMed 780G users, although unannounced meals of up to 30 g of CHO are safe.
找到碳水化合物（CHO）耐受阈值，以便在未通知的情况下食用零食，避免在高级混合闭环（a-HCL）使用者中出现餐后 2 小时血糖升高（餐前和餐后血糖差值[ΔBG]）≥50mg/dL。
本研究纳入了 14 名患有 1 型糖尿病的儿童和青少年（女性 7 名；平均年龄[±SD]为 14.5±3.6 岁），他们使用美敦力 MiniMed 780G。在 12 天的时间里，他们在早餐前不进行胰岛素推注，规定了不同数量和类型的 CHO，有或没有脂肪，在餐前和餐后 2 小时测量血糖（BG）。
发现总 CHO 摄入量为 19.8 克可确定 ΔBG 为 50mg/dL。BG 从未超过 250mg/dL。每次零食后 2 小时内的时间在范围内的平均值≥70%。
MiniMed 780G 用户可以食用不超过 20 克 CHO 的未通知零食，以避免 ΔBG≥50mg/dL，但食用不超过 30 克 CHO 的未通知餐食是安全的。
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