Ministry of Education, College of Atmospheric Sciences, Key Laboratory of Semi-Arid Climate Change, Lanzhou University, Lanzhou, 730000, China.
Lanzhou Petrochemical Company, Lanzhou, 730060, China.
Environ Sci Pollut Res Int. 2022 Sep;29(45):67776-67786. doi: 10.1007/s11356-022-20585-4. Epub 2022 May 6.
In recent years, O pollution had been worsening in China and became a major challenge for human health. To evaluate the O effects on circulatory and respiratory mortality in Harbin, a high latitude city of northeast China, we applied a time-series study from 2014 to 2016. After collecting data and adjusting for the effects of confounders, we built the generalized additive model to assess the associations between O and mortality at different lag days. The results showed that an interquartile-range (IQR) increase in O concentration corresponded to excess risk (ER) of 2.00% (95%CI: - 0.25-4.30%) for circulatory mortality at lag 0 and 8.02% (95%CI: 4.18-12.01%) for respiratory mortality at lag 2 days in the single-pollutant model. Stratified analysis showed that O had a greater effect on females than on males. The effect of O exposure on circulatory mortality was stronger during the warm period, while the opposite trend was founded for respiratory mortality. The sensitivity analysis showed that the effects of O were relatively independent and the major results were robust.
近年来，中国的 O 污染日益严重，成为人类健康的主要挑战。为了评估 O 对中国东北地区高纬度城市哈尔滨循环系统和呼吸系统死亡率的影响，我们进行了一项 2014 年至 2016 年的时间序列研究。在收集数据并调整混杂因素的影响后，我们构建了广义相加模型来评估 O 浓度与滞后不同天数的死亡率之间的关联。结果表明，O 浓度每增加一个四分位距（IQR），循环系统死亡率的超额风险（ER）就会增加 2.00%（95%CI：-0.25-4.30%），滞后 0 天；呼吸系统死亡率的 ER 增加 8.02%（95%CI：4.18-12.01%），滞后 2 天。分层分析表明，O 对女性的影响大于男性。O 暴露对循环系统死亡率的影响在温暖期更强，而呼吸系统死亡率则相反。敏感性分析表明，O 的影响相对独立，主要结果稳健。
