Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
J Org Chem. 2022 May 20;87(10):6573-6587. doi: 10.1021/acs.joc.2c00139. Epub 2022 May 6.
A new chemistry of azo compounds, that is, addition of free radicals generated in situ to access various acyl hydrazides, has been developed. The protocol provides a novel strategy for the synthesis of valuable acyl hydrazides. The transformation features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. In view of the importance of acyl hydrazides in functional materials and medicinal chemistry, this approach would find broad applications.
一种新的偶氮化合物化学，即原位生成的自由基加成反应，已经被开发出来，用于合成各种酰基腙。该方案为酰基腙的合成提供了一种新的策略。该转化具有温和的反应条件、对官能团的良好耐受性和广泛的底物范围。鉴于酰基腙在功能材料和药物化学中的重要性，这种方法将会有广泛的应用。
