IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
Wiad Lek. 2022;75(3):584-589.
The aim: The study of the possibilities of oxidase-antioxidant system indicators regulation at patients with periodontitis under the influence of complex treatment.
Materials and methods: 36 healthy and 125 patients with chronic and exacerbated periodontitis of primary (22 and 21), I (21) and II (20) degrees were examined.Indicators of lipid peroxidation and antioxidant protection (levels of diene conjugates and malonic dialdehyde, catalase activity and transferrin iron saturation, ceruloplasmin activity) in the blood serum were studied before, 6 and 12 months after the appointed treatment. Initial periodontal therapy and a paste developed by us (spirulina microalgae powders and silica enterosorbent taken in equal amounts and 0.05% chlorhexidine bigluconate) for applications and instillations were exogenously used in the complex treatment. Spirulina tablets were prescribed per os as well.
Results: All patients exhibit elevated levels of diene conjugates and malonic dialdehyde, decreased catalase activity and transferrin iron saturation as well as an increased ceruloplasmin activity, especially pronounced at stages I and II (p1≤0.01-0.001). Treatment contributed to long-term and reliable (p2<0.05 - 0.001) regulation of the studied parameters: reduction of diene conjugates and malonic dialdehyde, ceruloplasmin activity and increased catalase activity and transferrin iron saturation. All indicators differed slightly from the norm during the year (p1>0.05), and complete normalization of most of them lasted six months. At the same time clinical stabilization of periodontitis was reached.
Conclusions: Indicators of the oxidase-antioxidant system in patients with periodontitis are significantly altered and indicate their participation in the pathogenesis of the disease. Complex treatment was able to almost completely normalize them within six months, but a year later the difference between the obtained indicators with data in healthy people was insignificant (except for ceruloplasmin). Clinical stabilization was achieved in all patients.
研究在复合治疗的影响下，牙周炎患者氧化还原系统指标调节的可能性。
共检查了 36 名健康者和 125 名慢性和加重性牙周炎患者，其中原发性牙周炎 22 例和 21 例，I 度 21 例和 II 度 20 例。研究了血清脂质过氧化和抗氧化保护指标（二烯结合物和丙二醛水平、过氧化氢酶活性和转铁蛋白铁饱和度、铜蓝蛋白活性），在指定治疗前、治疗后 6 个月和 12 个月进行了检查。初始牙周治疗和我们开发的糊剂（等量螺旋藻微藻粉和二氧化硅肠吸附剂和 0.05%葡萄糖酸氯己定）用于外源性应用和滴注，在复合治疗中使用。还规定了螺旋藻片剂口服。
所有患者均表现出二烯结合物和丙二醛水平升高，过氧化氢酶活性和转铁蛋白铁饱和度降低，以及铜蓝蛋白活性升高，尤其是在 I 期和 II 期更为明显（p1≤0.01-0.001）。治疗有助于长期和可靠地（p2<0.05-0.001）调节研究参数：降低二烯结合物和丙二醛、铜蓝蛋白活性以及增加过氧化氢酶活性和转铁蛋白铁饱和度。在一年内，所有指标均与正常值略有差异（p1>0.05），其中大多数指标的完全正常化持续了六个月。同时，牙周炎达到了临床稳定。
牙周炎患者的氧化还原系统指标明显改变，表明它们参与了疾病的发病机制。在六个月内，复合治疗几乎可以使它们完全正常化，但一年后，获得的指标与健康人群的数据之间的差异不显著（除了铜蓝蛋白）。所有患者均达到了临床稳定。
