Rodríguez-Laso Ángel, Martín-Lesende Iñaki, Sinclair Alan, Sourdet Sandrine, Tosato Matteo, Rodríguez-Mañas Leocadio
Instituto de Salud Carlos III, Madrid, Spain.
Indautxu Primary Health Centre, Bilbao-Basurto Integrated Health Organisation, Basque Health Service (Osakidetza), Bilbao, Spain.
BJGP Open. 2022 May 6;6(3). doi: 10.3399/BJGPO.2021.0220.
There is little knowledge of the diagnostic accuracy of screening programmes for frailty in primary care settings.
To assess a two-step strategy consisting of the administration of the FRAIL scale to those who are non-dependent, aged ≥75 years, followed-up by measurement of the Short Physical Performance Battery (SPPB) or gait speed in those who are positive.
DESIGN & SETTING: Cross-sectional and longitudinal cohort study. Analysis of primary care data from the FRAILTOOLS project at five European cities.
All patients consecutively attending were enrolled. They received the index tests plus the Fried phenotype and the frailty index to assess their frailty status. Mortality and worsening of dependency in basic (BADL) and instrumental (IADL) activities of daily living over a year were ascertained.
Prevalence of frailty based on frailty phenotype was 14.9% in the 362 participants. A FRAIL scale score ≥1 had a sensitivity of 83.3% (95%CI:73.1-93.6) to detect frailty. A positive result and a SPPB score <11 had a sensitivity of 72.2% (95%CI: 59.9-84.6); when combined with a gait speed <1.1 m/s, the sensitivity was 80% (95%CI: 68.5-91.5). Two thirds of those screened as positive were not frail. In the best scenario, sensitivities of this last combination to detect IADL and BADL worsening were 69.4% (95%CI: 59.4-79.4) and 63.6% (95%CI: 53.4-73.9).
Combining the FRAIL scale with other functional measures offers an acceptable screening approach for frailty. Accurate prediction of worsening dependency and death need to be confirmed through the piloting of a frailty screening programme.
在初级保健机构中,对于衰弱筛查项目的诊断准确性了解甚少。
评估一种两步策略,即对年龄≥75岁且无依赖的人群进行衰弱量表(FRAIL)评估,对结果呈阳性者进一步测量简短体能状况量表(SPPB)或步速。
横断面和纵向队列研究。对来自欧洲五个城市的FRAILTOOLS项目的初级保健数据进行分析。
连续就诊的所有患者均纳入研究。他们接受了指标测试以及Fried衰弱表型和衰弱指数评估其衰弱状态。确定了一年内基本日常生活活动(BADL)和工具性日常生活活动(IADL)中依赖情况的死亡率和恶化情况。
在362名参与者中,基于衰弱表型的衰弱患病率为14.9%。FRAIL量表评分≥1检测衰弱的敏感性为83.3%(95%置信区间:73.1 - 93.6)。阳性结果且SPPB评分<11的敏感性为72.2%(95%置信区间:59.9 - 84.6);当与步速<1.1米/秒相结合时,敏感性为80%(95%置信区间:68.5 - 91.5)。筛查为阳性的人群中有三分之二并非衰弱。在最佳情况下,最后这种组合检测IADL和BADL恶化的敏感性分别为69.4%(95%置信区间:59.4 - 79.4)和63.6%(95%置信区间:53.4 - 73.9)。
将FRAIL量表与其他功能测量方法相结合,为衰弱提供了一种可接受的筛查方法。需要通过衰弱筛查项目的试点来确认对依赖情况恶化和死亡的准确预测。