Dang Junwu, Zhang Shuai, You Shengnan, Du Wenjing, Xu Guizhi
State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, P.R.China.
Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Apr 25;39(2):267-275. doi: 10.7507/1001-5515.202108036.
Transcranial magneto-acoustic-electrical stimulation is a new non-invasive neuromodulation technology, in which the induced electric field generated by the coupling effect of ultrasound and static magnetic field are used to regulate the neural rhythm oscillation activity in the corresponding brain region. The purpose of this paper is to investigate the effects of transcranial magneto-acoustic-electrical stimulation on the information transfer and communication in neuronal clusters during memory. In the experiment, twenty healthy adult Wistar rats were randomly divided into a control group (five rats) and stimulation groups (fifteen rats). Transcranial magneto-acoustic-electrical stimulation of 0.050.15 T and 2.6613.33 W/cm was applied to the rats in stimulation groups, and no stimulation was applied to the rats in the control group. The local field potentials signals in the prefrontal cortex of rats during the T-maze working memory tasks were acquired. Then the coupling differences between delta rhythm phase, theta rhythm phase and gamma rhythm amplitude of rats in different parameter stimulation groups and control group were compared. The experimental results showed that the coupling intensity of delta and gamma rhythm in stimulation groups was significantly lower than that in the control group ( <0.05), while the coupling intensity of theta and gamma rhythm was significantly higher than that in the control group ( <0.05). With the increase of stimulation parameters, the degree of coupling between delta and gamma rhythm showed a decreasing trend, while the degree of coupling between theta and gamma rhythm tended to increase. The preliminary results of this paper indicated that transcranial magneto-acoustic-electrical stimulation inhibited delta rhythmic neuronal activity and enhanced the oscillation of theta and gamma rhythm in the prefrontal cortex, thus promoted the exchange and transmission of information between neuronal clusters in different spatial scales. This lays the foundation for further exploring the mechanism of transcranial magneto-acoustic-electrical stimulation in regulating brain memory function.
经颅磁声电刺激是一种新型非侵入性神经调节技术，其中利用超声与静磁场的耦合效应所产生的感应电场来调节相应脑区的神经节律振荡活动。本文旨在研究经颅磁声电刺激对记忆过程中神经元集群内信息传递与交流的影响。实验中，将20只健康成年Wistar大鼠随机分为对照组（5只大鼠）和刺激组（15只大鼠）。对刺激组大鼠施加0.050.15T和2.6613.33W/cm的经颅磁声电刺激，对照组大鼠不施加刺激。采集大鼠在T迷宫工作记忆任务期间前额叶皮质的局部场电位信号。然后比较不同参数刺激组大鼠与对照组大鼠在δ节律相位、θ节律相位和γ节律幅度之间的耦合差异。实验结果表明，刺激组中δ与γ节律的耦合强度显著低于对照组（P<0.05），而θ与γ节律的耦合强度显著高于对照组（P<0.05）。随着刺激参数的增加，δ与γ节律之间的耦合程度呈下降趋势，而θ与γ节律之间的耦合程度呈上升趋势。本文的初步结果表明，经颅磁声电刺激抑制了前额叶皮质中δ节律性神经元活动，增强了θ和γ节律的振荡，从而促进了不同空间尺度神经元集群之间的信息交换与传递。这为进一步探索经颅磁声电刺激调节脑记忆功能的机制奠定了基础。
