土耳其老年人群体中使用 SARS-CoV-2 灭活疫苗（科兴疫苗）的抗体反应。
Antibody response with SARS-CoV-2 inactivated vaccine (CoronaVac) in Turkish geriatric population.
机构信息
Department of Internal Medicine, Division of Geriatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Ankara City Hospital Laboratory, Siemens Healthineers, Ankara, Turkey.
出版信息
Age Ageing. 2022 May 1;51(5). doi: 10.1093/ageing/afac088.
BACKGROUND
Sars-CoV-2 infection influences older individuals at the forefront, and there is still limited data on the COVID-19 vaccine response in the geriatric population. This study aimed to assess antibody response after vaccination with SARS-CoV-2 inactivated vaccine and examine possible factors affecting this response in a geriatric population.
METHODS
individuals who have been on at least the 28th day after the second dose of the COVID-19 vaccine were included. Comprehensive geriatric assessment tools and the Clinical Frailty Scale were performed. SARS-CoV-2 spike-specific IgG antibodies were detected and, levels ≥1 U/ml were defined as seropositive, <1 U/ml were defined as seronegative.
RESULTS
a total of 497 patients were included and divided into three groups according to the days past after the second dose of the vaccine (Group 1: 28-59 days, Group 2: 60-89 days and Group 3: 90 days and more). Groups included 188, 148 and 171 patients, respectively. Seropositivity rate in each group was 80.9,73.2 and 57.3%, respectively. In Groups 1 and 2, Charlson Comorbidity Index score was higher in the seronegative group (P = 0.023 and P = 0.011, respectively). In Group 3, the prevalence of frailty was significantly higher in the seronegative group (P = 0.002).
CONCLUSION
to the best of our knowledge, this is the first study assessing the antibody response after vaccination with Sars-CoV 2 inactivated vaccine in the Turkish geriatric population. Moreover, this is the first study revealing the relationship between antibody response and frailty. Larger studies are needed to confirm the antibody response duration and the association between frailty and COVID-19 vaccine response.
背景
Sars-CoV-2 感染对老年人影响较大，而关于老年人 COVID-19 疫苗反应的资料仍有限。本研究旨在评估 Sars-CoV-2 灭活疫苗接种后的抗体反应，并探讨老年人群中影响这种反应的可能因素。
方法
纳入至少在第二剂 COVID-19 疫苗接种后 28 天的患者。采用全面老年评估工具和临床虚弱量表进行评估。检测 Sars-CoV-2 刺突特异性 IgG 抗体，≥1 U/ml 定义为阳性，<1 U/ml 定义为阴性。
结果
共纳入 497 例患者，根据第二剂疫苗接种后天数分为三组（第 1 组：28-59 天，第 2 组：60-89 天，第 3 组：90 天及以上）。各组分别包括 188、148 和 171 例患者。各组的阳性率分别为 80.9%、73.2%和 57.3%。在第 1 组和第 2 组中，阴性组的 Charlson 合并症指数评分较高（P=0.023 和 P=0.011）。在第 3 组中，阴性组的虚弱发生率明显较高（P=0.002）。
结论
据我们所知，这是第一项评估土耳其老年人群中 Sars-CoV 2 灭活疫苗接种后抗体反应的研究。此外，这是第一项揭示抗体反应与虚弱之间关系的研究。需要更大规模的研究来确认抗体反应持续时间以及虚弱与 COVID-19 疫苗反应之间的关系。
Zotero 插件