Greenlane Cardiothoracic Unit, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Department of Radiology, Auckland City Hospital, Auckland, New Zealand.
Gen Thorac Cardiovasc Surg. 2022 Nov;70(11):971-976. doi: 10.1007/s11748-022-01826-2. Epub 2022 May 7.
The spectrum of ground glass opacity (GGO) is a diagnostic and clinical management quandary. The role of computed tomographic scans in detecting malignant GGO has inter-observer variability. Pure GGO have been traditionally thought to be predominantly benign in nature and has long volume doubling times. This study was undertaken to correlate the findings of radiology and histology of ground glass opacities at our institute.
This study is a retrospective observational study of patients who underwent lung resection surgery for radiology proven ground glass opacities between January 2010 and December 2018. A total of 115 patients were included in the study based on inclusion and exclusion criteria and were analysed.
The patients were divided into two groups; pure GGO (n = 50), mixed GGO (n = 65). The pathological tumour size was ≤ 2 cm in 51% of the patients and 27 patients had the size between 2.1 and 3.0 cm. The predominant histopathologic feature was lepidic predominance in 54 patients followed by 24 patients with acinar predominance. Among patients with radiological tumour size of ≤ 2 cm, pure GGO was present in 48% of the patients. Among patients with pure GGO, 96% of the patients had no solid component. 44 patients had only single CT scan before proceeding to surgery. All these patients had mixed GGO.
Our study concludes pure GGOs, though lacking solid component have a high propensity to be malignant. The role of repeated CT surveillance in this context without offering curative surgery may be questionable.
磨玻璃密度（GGO）的范围是一个诊断和临床管理的难题。计算机断层扫描在检测恶性 GGO 方面的作用存在观察者间的变异性。纯 GGO 传统上被认为主要是良性的，倍增时间较长。本研究旨在探讨我们机构的 GGO 放射学和组织学表现。
这是一项回顾性观察性研究，纳入了 2010 年 1 月至 2018 年 12 月期间因放射学证实的 GGO 而接受肺切除术的患者。根据纳入和排除标准，共有 115 例患者纳入研究并进行分析。
患者分为两组：纯 GGO（n=50）和混合 GGO（n=65）。患者肿瘤大小均≤2cm，占 51%，27 例患者肿瘤大小在 2.1-3.0cm 之间。主要的组织病理学特征是 54 例以贴壁生长为主，24 例以腺泡生长为主。在肿瘤大小均≤2cm 的患者中，纯 GGO 占 48%。在纯 GGO 患者中，96%的患者无实性成分。44 例患者术前仅行单次 CT 扫描，均为混合 GGO。
我们的研究表明，虽然缺乏实性成分的纯 GGO 具有较高的恶性倾向。但在这种情况下，不提供治愈性手术而反复进行 CT 监测的作用可能值得质疑。
