Environmental Biotechnology and Genomics Division, CSIR- National Environmental Engineering Research Institute (NEERI), Nagpur, 440020, India.
Environmental Biotechnology and Genomics Division, CSIR- National Environmental Engineering Research Institute (NEERI), Nagpur, 440020, India.
Environ Res. 2022 Sep;212(Pt C):113359. doi: 10.1016/j.envres.2022.113359. Epub 2022 May 5.
Worldwide growing concerns about water contamination and pollution have increased significant interest in trace level sensing of variety of contaminants. Thus, there is demand for fabrication of low cost, miniaturized sensing device for in-situ detection of contaminants from the complex environmental matrices capable of providing selective and sensitive detection. Molecularly imprinted polymers (MIPs) has portrayed a substantial potential for selective recognition of various toxicants from a variety of environmental matrices, thus widely used as artificial recognition element in the electrochemical sensors (ECS) owing to their chemical stability, easy and low cost synthesis. The combination of nanomaterials modifiers with MIPs has endowed MIP-ECS with significantly improved sensing performance in the recent years, as the nanomaterial provide properties such as increased surface area, increased conductivity and electrocatalytic activity with enhanced electron transport phenomena, whereas MIPs provide selective recognition effect. In the present review, we have summarized the advances of MIP-ECS electrochemical sensors reported in last six years (2017-2022) for sensing of variety of contaminates including drugs, metal ions, hormones and emerging contaminates. Scope of computational modelling in design of sensitive and selective MIP-ECS is reviewed. We have focused particularly on the synthetic protocols for MIPs preparation including bulk, precipitation, electropolymerization, sol-gel and magnetic MIPs. Moreover, use of various nanomaterial as modifiers and sensitizers and their effects on the sensing performance of resulting MIP-ECS is described. Finally, the potential challenges and future prospects in the research area of MIP-ECS have been discussed.
全球范围内对水污染和污染的日益关注，极大地增加了对各种污染物痕量水平传感的兴趣。因此，需要制造低成本、微型化的传感装置，以便从复杂的环境基质中现场检测污染物，从而提供选择性和灵敏的检测。分子印迹聚合物（MIPs）在从各种环境基质中选择性识别各种有毒物质方面表现出巨大的潜力，因此由于其化学稳定性、易于合成和低成本，被广泛用作电化学传感器（ECS）中的人工识别元件。纳米材料修饰剂与 MIPs 的结合在近年来赋予了 MIP-ECS 显著改善的传感性能，因为纳米材料提供了增加的表面积、增加的导电性和电催化活性以及增强的电子传递现象，而 MIPs 则提供了选择性识别效果。在本综述中，我们总结了过去六年（2017-2022 年）报道的用于检测各种污染物（包括药物、金属离子、激素和新兴污染物）的 MIP-ECS 电化学传感器的进展。我们审查了计算建模在设计敏感和选择性 MIP-ECS 方面的应用。我们特别关注 MIPs 制备的合成方案，包括本体、沉淀、电化学聚合、溶胶-凝胶和磁性 MIPs。此外，还描述了各种纳米材料作为修饰剂和敏化剂的用途及其对所得 MIP-ECS 传感性能的影响。最后，讨论了 MIP-ECS 研究领域的潜在挑战和未来前景。
