Advances in fabrication of molecularly imprinted electrochemical sensors for detection of contaminants and toxicants.

Worldwide growing concerns about water contamination and pollution have increased significant interest in trace level sensing of variety of contaminants. Thus, there is demand for fabrication of low cost, miniaturized sensing device for in-situ detection of contaminants from the complex environmental matrices capable of providing selective and sensitive detection. Molecularly imprinted polymers (MIPs) has portrayed a substantial potential for selective recognition of various toxicants from a variety of environmental matrices, thus widely used as artificial recognition element in the electrochemical sensors (ECS) owing to their chemical stability, easy and low cost synthesis. The combination of nanomaterials modifiers with MIPs has endowed MIP-ECS with significantly improved sensing performance in the recent years, as the nanomaterial provide properties such as increased surface area, increased conductivity and electrocatalytic activity with enhanced electron transport phenomena, whereas MIPs provide selective recognition effect. In the present review, we have summarized the advances of MIP-ECS electrochemical sensors reported in last six years (2017-2022) for sensing of variety of contaminates including drugs, metal ions, hormones and emerging contaminates. Scope of computational modelling in design of sensitive and selective MIP-ECS is reviewed. We have focused particularly on the synthetic protocols for MIPs preparation including bulk, precipitation, electropolymerization, sol-gel and magnetic MIPs. Moreover, use of various nanomaterial as modifiers and sensitizers and their effects on the sensing performance of resulting MIP-ECS is described. Finally, the potential challenges and future prospects in the research area of MIP-ECS have been discussed.