Cornell University College of Veterinary Medicine, Ithaca, NY, 14853, USA.
University of Saskatchewan Western College of Veterinary Medicine, Saskatoon, S7N 5B4, Canada.
J Avian Med Surg. 2022 May;36(1):21-27. doi: 10.1647/20-00111.
The objective of this study was to compare the sedative effects of intramuscular alfaxalone combined with either ketamine or midazolam in chickens (). A prospective, randomized blinded crossover study design with a 7-day washout period was used. Nine adult layer hens received alfaxalone 15 mg/kg with ketamine 5 mg/kg IM (treatment AK) or alfaxalone 15 mg/kg with midazolam 1 mg/kg IM (treatment AM). Time to lateral recumbency, time to loss of righting reflex, induction quality, duration of loss of righting reflex, time to sternal recumbency or vigorous response to stimulation, and time to standing were recorded. Muscle tone, response to noxious stimulation, heart rate, respiratory rate, and oxygen saturation were monitored once the righting reflex was absent. Induction and recovery times were not different between treatments. Lateral recumbency was induced in 8 of 9 birds receiving AK compared to 6 of 9 birds receiving AM. Righting reflex was absent in 7 of 9 and 5 of 9 chickens administered AK and AM, respectively. Median time to loss of righting reflex for AK and AM were 5.5 (4.3-9.3) minutes and 9.1 (4.8-15.0) minutes, respectively ( = .88). Median duration of loss of righting reflex was 21.6 (16.0-36.9) minutes for AK and 21.1 (11.9-26.4) minutes for AM ( = .38). Alfaxalone-ketamine resulted in moderate excitation during induction. Further investigations are warranted to investigate the effects of alfaxalone and midazolam or ketamine at different doses.
本研究旨在比较肌肉注射氟烷酮联合氯胺酮或咪达唑仑在鸡中的镇静效果。采用 7 天洗脱期的前瞻性、随机、双盲交叉研究设计。9 只成年层鸡分别接受氟烷酮 15mg/kg 联合氯胺酮 5mg/kg（AK 组）或氟烷酮 15mg/kg 联合咪达唑仑 1mg/kg（AM 组）肌肉注射。记录侧卧时间、翻正反射丧失时间、诱导质量、翻正反射丧失时间、胸骨卧位或刺激后剧烈反应时间和站立时间。当翻正反射消失时，监测肌肉张力、对有害刺激的反应、心率、呼吸频率和血氧饱和度。两种处理方式的诱导和恢复时间无差异。8 只接受 AK 治疗的鸡出现侧卧，而 6 只接受 AM 治疗的鸡出现侧卧。7 只接受 AK 治疗的鸡和 5 只接受 AM 治疗的鸡的翻正反射消失，中位数时间分别为 5.5（4.3-9.3）分钟和 9.1（4.8-15.0）分钟（ =.88）。AK 和 AM 组的中位翻正反射丧失时间分别为 21.6（16.0-36.9）分钟和 21.1（11.9-26.4）分钟（ =.38）。氟烷酮-氯胺酮诱导时产生中度兴奋。需要进一步研究以研究不同剂量的氟烷酮和咪达唑仑或氯胺酮的作用。
