Robert Khumalo Mandlenkosi, Maddila Surya Narayana, Maddila Suresh, Jonnalagadda Sreekantha B
School of Chemistry & Physics, University of KwaZulu-Natal Westville Campus, Chiltern Hills Durban 4000 South Africa
RSC Adv. 2019 Sep 30;9(53):30768-30772. doi: 10.1039/c9ra04604f. eCollection 2019 Sep 26.
A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-]-quinolines at ambient temperature in aqueous ethanol as a reaction medium. The 18 novel pyrazolo-[3,4-]-quinoline derivatives were synthesized by fusion of chosen aryl aldehyde, dimedone and 5-amino-3-methyl-1-phenylpyrazole in excellent yields (91-98%). All the molecular structures were confirmed by H-NMR, N-NMR, C-NMR, and HRMS data analysis. Operational simplicity, easy handling, one-step simple workup procedure, mild reaction conditions, short reaction time (≤10 min), high selectivity and no by-product formation are the striking features of the protocol.
设计了一种简便、快速且环保的微波辅助多组分/一锅法方案，用于在室温下以乙醇水溶液为反应介质合成新型吡唑并[3,4 - ]喹啉。通过选定的芳醛、达米酮和5 - 氨基 - 3 - 甲基 - 1 - 苯基吡唑的缩合反应，以优异的产率（91 - 98%）合成了18种新型吡唑并[3,4 - ]喹啉衍生物。所有分子结构均通过H - NMR、N - NMR、C - NMR和HRMS数据分析得到证实。该方案的显著特点包括操作简单、易于处理、一步简单后处理程序、温和的反应条件、短反应时间（≤10分钟）、高选择性且无副产物生成。
