Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, South Korea.
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.
Int J Biol Macromol. 2022 Jun 15;210:1-10. doi: 10.1016/j.ijbiomac.2022.05.005. Epub 2022 May 5.
Owing to the destruction of ozone layer, the increased exposure to UV on the earth adversely affects not only skin diseases but also wound healing. Although the demand for sunscreens is increasing to protect the human skin from these adverse effects, commercially available sunscreens have some limitations in safety. In this study, silk fibroin (SF) composite with biocompatibility and blood coagulation activity was prepared for a highly safe sunscreen. However, the SF has a disadvantage in that it is difficult to dissolve in water. To improve the solubility of SF, butyl glycidyl ether (BGE) was reacted with the side chain of SF to prepare a freely water-soluble SF (mSF) derivative, and the phase behavior according to the mixing ratio of SF derivative and tannic acid (TA) was observed. In addition, ZnO nanoparticles were added to the mSF-TA solution to form a hydrogel through the coordination bonding. The UV blocking, hemostatic, antibacterial and antioxidant effects of the mSF/TA/ZnO composite hydrogel were evaluated, and the excellent skin compatibility of multifunctional hydrogel sunscreen was confirmed through a skin irritation test.
由于臭氧层的破坏，地球上紫外线的增加不仅对皮肤病，而且对伤口愈合都有不利影响。虽然为了保护人体皮肤免受这些不利影响，对防晒霜的需求正在增加，但市售的防晒霜在安全性方面存在一些局限性。在这项研究中，制备了具有生物相容性和凝血活性的丝素蛋白 (SF) 复合材料，以获得高度安全的防晒霜。然而，SF 的缺点是它很难溶解在水中。为了提高 SF 的溶解度，用丁基缩水甘油醚 (BGE) 与 SF 的侧链反应，制备了一种可自由溶解于水的 SF（mSF）衍生物，并观察了 SF 衍生物和单宁酸 (TA) 的混合比的相行为。此外，将 ZnO 纳米粒子添加到 mSF-TA 溶液中，通过配位键形成水凝胶。评估了 mSF/TA/ZnO 复合水凝胶的紫外线阻断、止血、抗菌和抗氧化作用，并通过皮肤刺激试验证实了多功能水凝胶防晒霜的出色皮肤相容性。
