Ke Xiang, Tang Shuxian, Dong Zhiyun, Wang Hao, Xu Xinyuan, Qiu Rongmin, Yang Jiaojiao, Luo Jun, Li Jianshu
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.
College & Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning 530021, China.
Int J Biol Macromol. 2022 Jun 1;209(Pt A):608-617. doi: 10.1016/j.ijbiomac.2022.03.136. Epub 2022 Mar 30.
Bioadhesives have gained considerable popularity for application in wound closure. However, applying bioadhesives incurs risks associated with bacterial infection during wound healing. Hence, in this study, a silk fibroin based bioadhesive was constructed via employing natural macromolecule, silk fibroin (SF), to spontaneously coassemble with natural plant polyphenol, tannic acid (TA), and iron oxide nanoparticles (FeO NPs). In the system, the natural macromolecule SF plays a key role in fabricating the macromolecular network matrix due to the change of the secondary structure of SF (from random coil to β-sheet) under the trigger of TA. Importantly, the strong hydrogen bonding interactions between SF and TA, and the coordination bonds between TA and FeO NPs endow the bioadhesive with high extensibility, self-healing properties, and considerable wet adhesion. Meanwhile, the synergy between the inherent photothermal properties of FeO NPs and TA/Fe complexes under near-infrared (NIR) radiation enables the bioadhesive superior photothermal-reinforced antibacterial activity. The multifunctional natural macromolecule bioadhesive is a potential candidate in clinical wound management for improved outcomes, especially in infected wounds.
生物粘合剂在伤口闭合应用中已颇受欢迎。然而，使用生物粘合剂会带来伤口愈合期间与细菌感染相关的风险。因此，在本研究中，通过利用天然大分子丝素蛋白（SF）与天然植物多酚单宁酸（TA）以及氧化铁纳米颗粒（FeO NPs）自发共组装，构建了一种基于丝素蛋白的生物粘合剂。在该体系中，天然大分子SF在制造大分子网络基质中起关键作用，这是由于在TA的触发下SF的二级结构发生了变化（从无规卷曲变为β折叠）。重要的是，SF与TA之间的强氢键相互作用以及TA与FeO NPs之间的配位键赋予了生物粘合剂高延展性、自愈性能和可观的湿粘性。同时，FeO NPs的固有光热特性与TA/Fe络合物在近红外（NIR）辐射下的协同作用使生物粘合剂具有卓越的光热增强抗菌活性。这种多功能天然大分子生物粘合剂是临床伤口管理中改善治疗效果的潜在候选物，尤其是在感染伤口方面。
