Kashif Hadi, Abuelgasim Eyad, Hussain Nafisa, Luyt Jessica, Harky Amer
UCL Medical School, University College London, London, United Kingdom.
Faculty of Medicine, Imperial College London, London, United Kingdom.
Ann Pediatr Cardiol. 2021 Oct-Dec;14(4):507-515. doi: 10.4103/apc.apc_30_21. Epub 2022 Mar 25.
Necrotizing enterocolitis (NEC) remains a prominent surgical emergency among infant population, associated with a significant mortality, as well as various subsequent morbidities. Congenital heart disease (CHD) has an increased associated incidence with NEC in infant population. Recent research has provided insight into the pathophysiology of NEC in patients with CHD and how this differs from those without CHD. The deviation from normal circulatory physiology has a suggested association in the pathophysiology of NEC in CHD, which may have implications for the risk factors of NEC in infants with CHD, the effect on outcomes of NEC, and whether alternative approaches to management may need to be considered in comparison to classical NEC. This review aims to highlight studies that provide insight and awareness into the relationship between NEC and CHD, in order that clinicians may direct themselves more clearly toward optimal management for infants in this category.
坏死性小肠结肠炎（NEC）仍是婴儿群体中一种突出的外科急症，伴有显著的死亡率以及各种后续并发症。先天性心脏病（CHD）在婴儿群体中与NEC的关联发病率有所增加。最近的研究深入探讨了患有CHD的患者中NEC的病理生理学，以及其与未患CHD的患者有何不同。正常循环生理学的偏离在CHD的NEC病理生理学中被认为存在关联，这可能对患有CHD的婴儿发生NEC的风险因素、NEC对预后的影响，以及与经典NEC相比是否需要考虑其他管理方法具有启示意义。本综述旨在突出那些深入探讨NEC与CHD之间关系的研究，以便临床医生能更明确地针对这一类别婴儿进行优化管理。
