坏死性小肠结肠炎认识方面的最新进展
Recent advances in understanding necrotizing enterocolitis.
作者信息
Alganabi Mashriq, Lee Carol, Bindi Edoardo, Li Bo, Pierro Agostino
机构信息
Division of General and Thoracic Surgery, Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
F1000Res. 2019 Jan 25;8. doi: 10.12688/f1000research.17228.1. eCollection 2019.
Abstract
Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially in infants with advanced disease. The mechanism of disease development, the progression of intestinal injury, and management remain areas of ongoing research and controversy. In this review, we examine our current understanding of the disease, its epidemiology, the risk factors associated with the development of the disease, and its pathophysiology. We also describe current management and new emerging research highlighting potential future directions.
摘要
坏死性小肠结肠炎是一种影响早产儿的毁灭性肠道疾病。尽管新生儿护理方面的研究不断推进，但死亡率仍然很高，尤其是患有晚期疾病的婴儿。疾病发展机制、肠道损伤的进展以及治疗方法仍是持续研究和存在争议的领域。在本综述中，我们审视了目前对该疾病的认识、其流行病学、与疾病发展相关的危险因素及其病理生理学。我们还描述了当前的治疗方法以及突出潜在未来方向的新出现的研究。
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