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纳尔雅他宁A和B，一对具有2,3-环烯醚萜骨架且带有不寻常的1,10-氧桥的新型差向异构体及其对阿尔茨海默病中蠕虫麻痹作用的评估。

Narjatamanins A and B, a pair of novel epimers possessing a 2,3--iridoid skeleton with an unusual 1,10-oxygen bridge from and evaluation of their effects on worm paralysis in AD .

作者信息

Zhao Ye, Li Bing, Yu Yi-Fan, Wu Pei-Qian, Yu Chun-Xue, Su Pan-Jie, Zhi De-Juan, Qi Feng-Ming, Fei Dong-Qing, Zhang Zhan-Xin

机构信息

School of Pharmacy, Lanzhou University Lanzhou 730000 People's Republic of China

State Key Laboratory of Applied Organic Chemistry, Lanzhou University Lanzhou 730000 People's Republic of China.

出版信息

RSC Adv. 2019 Aug 6;9(42):24333-24337. doi: 10.1039/c9ra04485j. eCollection 2019 Aug 2.

DOI:10.1039/c9ra04485j
PMID:35527903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069666/
Abstract

Narjatamanins A (1) and B (2), a pair of epimers possessing a novel 2,3--iridoid skeleton with an unusual 1,10-oxygen bridge, were isolated from the whole plants of . Their structures were elucidated by a combination of various spectroscopic methods, including HRESIMS, IR and 1D and 2D NMR techniques. The absolute configurations of 1 and 2 were established by electronic circular dichroism (ECD) calculations. The pharmacological activities of 1 and 2 to alleviate AD-like symptoms were also evaluated using the Alzheimer's disease (AD) pathological model, and narjatamanins A (1) and B (2) showed statistically significant delay in the worm paralysis phenotype of AD-like symptoms.

摘要

从……的全株植物中分离得到了一对差向异构体——纳加他曼宁A（1）和B（2），它们具有一种带有不寻常的1,10 - 氧桥的新型2,3 - 环烯醚萜骨架。通过多种光谱方法相结合，包括高分辨电喷雾电离质谱（HRESIMS）、红外光谱（IR）以及一维和二维核磁共振（NMR）技术，阐明了它们的结构。通过电子圆二色光谱（ECD）计算确定了1和2的绝对构型。还使用阿尔茨海默病（AD）病理模型评估了1和2缓解类AD症状的药理活性，纳加他曼宁A（1）和B（2）在类AD症状的蠕虫麻痹表型上显示出具有统计学意义的延迟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/34c4cab7a2a2/c9ra04485j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/311bc11debb1/c9ra04485j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/9862744ae0c6/c9ra04485j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/e949d4defccb/c9ra04485j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/c04007eb3937/c9ra04485j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/caa50f38fd0c/c9ra04485j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/34c4cab7a2a2/c9ra04485j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/311bc11debb1/c9ra04485j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/9862744ae0c6/c9ra04485j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/e949d4defccb/c9ra04485j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/c04007eb3937/c9ra04485j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/caa50f38fd0c/c9ra04485j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a36/9069666/34c4cab7a2a2/c9ra04485j-f6.jpg

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Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis.从甘松中分离得到的 4 种新型倍半萜及其抗阿尔茨海默病活性。
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