Wang Chao, Yang Xinzhou, Mellick George D, Feng Yunjiang
Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.
Medical School, Wuhan University of Science and Technology, Wuhan 430065, People's Republic of China.
J Nat Prod. 2022 Apr 22;85(4):899-909. doi: 10.1021/acs.jnatprod.1c01021. Epub 2022 Feb 25.
A pair of novel serratane-related triterpenoid epimers, phlegmacaritones A () and B (), possessing an unprecedented 15,30-lactone-14,15-seco skeleton, six new serratane-type triterpenoids, phlegmanols G-L (- and -), and 16 known compounds were isolated from the whole plant of . The structures of the new metabolites were established on the basis of comprehensive spectroscopic data analysis and electronic circular dichroism calculations. A possible biosynthetic pathway for phlegmacaritones A () and B () was proposed. All compounds were submitted to cytological profiling on a cell line derived from a patient with Parkinson's disease. Phlegmacaritone B () induced a distinct phenotypic profile with alterations in α-tubulin, mitochondria, and autophagosomal and early endosomal features.
从[植物名称]的全株中分离出一对新型的与锯齿烷相关的三萜差向异构体，即茯苓萜A（）和B（），它们具有前所未有的15,30-内酯-14,15-断骨架，六个新的锯齿烷型三萜，茯苓醇G-L（-和-），以及16个已知化合物。通过综合光谱数据分析和电子圆二色性计算确定了新代谢产物的结构。提出了茯苓萜A（）和B（）可能的生物合成途径。所有化合物都在源自帕金森病患者的细胞系上进行了细胞学分析。茯苓萜B（）诱导了明显的表型特征，包括α-微管蛋白、线粒体以及自噬体和早期内体特征的改变。
