IL2RB是一种与泛癌免疫浸润相关的预后生物标志物。
IL2RB Is a Prognostic Biomarker Associated with Immune Infiltrates in Pan-Cancer.
作者信息
Li Guangyao, Wang Yandong, Cheng Ya
机构信息
The Second People's Hospital of Wuhu, Department of Gastrointestinal Surgery, East China Normal University, Wuhu 241000, China.
Wuhu Clinical College Affiliated to Nantong University, Wuhu 241000, China.
出版信息
J Oncol. 2022 Apr 29;2022:2043880. doi: 10.1155/2022/2043880. eCollection 2022.
BACKGROUND
Interleukin-2 receptor (IL2RB) is a receptor protein of interleukin-2. IL2RB is implicated in regulation of T cell-mediated immune response. However, the role of IL2RB in pan-cancer is unknown. The present premise sought to explore the role of IL2RB in tumorigenesis, tumor metabolism, and tumor immunity in pan-cancer.
METHODS
Data were retrieved from multiple data resources including GTEx data resource, CCLE data resource, TCGA data resource, UCSC data resource, and TISIDB web server. These data were adopted to assess the expression, prognosis value, relationship between IL2RB and immune microenvironment, microsatellite instability, immune new antigen, gene mutation, immune modulatory factors immune checkpoint and TMB, and immune or molecular subtypes of IL2RB in various tumors. Estimate analysis and GSEA were conducted to assess the role of IL2RB in pan-cancer.
RESULTS
Differential analysis illustrated that L2RB was remarkably elevated in pan-cancer, notably in solid tumors compared with normal tissues. Survival analysis indicated that IL2RB was linked to pan-cancer prognosis, and elevated IL2RB contents were remarkably linked to dismal prognosis patients in diverse kinds of cancers. The findings illustrated that IL2RB contents were remarkably linked to tumor immune invasion, tumor microenvironment, TMB, MSI, DNA repair genes, methyl transferases, immune modulatory factors, and immune or molecular subtypes in pan-cancer. IL2RB gene mutation was evident in numerous cancers. The data illustrated that IL2RB contents were remarkably enriched in multiple signaling cascades which modulate tumorigenesis, tumor metabolism along with immunity.
CONCLUSION
The findings of the present premise illustrate that IL2RB plays an indispensible role in tumorigenesis, tumor metabolism, and immunity. Therefore, it is a prospective target gene in tumor-target therapy and tumor immune therapy. IL2RB is also a valuable predictive biomarker in most solid tumors.
背景
白细胞介素-2受体（IL2RB）是白细胞介素-2的一种受体蛋白。IL2RB参与T细胞介导的免疫反应调节。然而，IL2RB在泛癌中的作用尚不清楚。本研究旨在探讨IL2RB在泛癌的肿瘤发生、肿瘤代谢和肿瘤免疫中的作用。
方法
从多个数据资源中检索数据，包括GTEx数据资源、CCLE数据资源、TCGA数据资源、UCSC数据资源和TISIDB网络服务器。采用这些数据评估IL2RB在各种肿瘤中的表达、预后价值、与免疫微环境的关系、微卫星不稳定性、免疫新抗原、基因突变、免疫调节因子、免疫检查点和肿瘤突变负荷（TMB），以及免疫或分子亚型。进行估计分析和基因集富集分析（GSEA）以评估IL2RB在泛癌中的作用。
结果
差异分析表明，IL2RB在泛癌中显著升高，尤其是在实体瘤中与正常组织相比。生存分析表明，IL2RB与泛癌预后相关，IL2RB含量升高与多种癌症中预后不良的患者显著相关。研究结果表明，IL2RB含量与泛癌中的肿瘤免疫浸润、肿瘤微环境、TMB、微卫星高度不稳定（MSI）、DNA修复基因、甲基转移酶、免疫调节因子以及免疫或分子亚型显著相关。IL2RB基因突变在多种癌症中明显。数据表明，IL2RB含量在调节肿瘤发生、肿瘤代谢以及免疫的多个信号级联中显著富集。
结论
本研究结果表明，IL2RB在肿瘤发生、肿瘤代谢和免疫中起不可或缺的作用。因此，它是肿瘤靶向治疗和肿瘤免疫治疗中的一个潜在靶基因。IL2RB也是大多数实体瘤中有价值的预测生物标志物。
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