Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
A & S Research Institute, Ministry of Science Research and Technology, Tehran, Iran.
J Obes. 2022 Apr 26;2022:1015669. doi: 10.1155/2022/1015669. eCollection 2022.
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong link between hyperglycemia, oxidative stress, inflammation, and the development of diabetes mellitus. PI3K/Akt/mTOR is the main signaling pathway of insulin for controlling lipid and glucose metabolism. P-cymene is an aromatic monoterpene with a widespread range of therapeutic properties including antioxidant and anti-inflammatory activity. In the present study, the antidiabetic effects of p-cymene were investigated. Diabetes was induced using streptozotocin in male Wistar rats. The effects of p-cymene and metformin were studied on levels of glucose (Glu), lipid profile, liver enzymes, oxidative stress, and the expression of Akt, phospho-Akt, and mTOR (mammalian target of rapamycin) proteins, using biochemical, histological, and immunohistochemical analysis. Data have shown that p-cymene can improve serum levels of Glu, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and the expression of mTOR, Akt, and phospho-Akt protein in diabetic animals. These results suggest that p-cymene has hypoglycemia, hypolipidemia, and antioxidant properties. It can regulate Akt/mTOR pathway and reduce hepatic and pancreas injury. It can be suggested for diabetes management alone or simultaneously with metformin.
糖尿病是中低收入国家严重的公共卫生问题。高血糖、氧化应激、炎症与糖尿病的发生之间存在密切关系。PI3K/Akt/mTOR 是胰岛素控制脂质和葡萄糖代谢的主要信号通路。对伞花烃是一种具有广泛治疗特性的单萜类芳香化合物，具有抗氧化和抗炎活性。本研究旨在探讨对伞花烃的抗糖尿病作用。雄性 Wistar 大鼠使用链脲佐菌素诱导糖尿病。使用生化、组织学和免疫组织化学分析，研究对伞花烃和二甲双胍对血糖（Glu）、血脂谱、肝酶、氧化应激以及 Akt、磷酸化 Akt 和 mTOR（雷帕霉素靶蛋白）蛋白表达的影响。数据表明，对伞花烃可改善糖尿病动物血清中 Glu、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、丙二醛（MDA）和 mTOR、Akt、磷酸化 Akt 蛋白的表达。这些结果表明，对伞花烃具有降血糖、降血脂和抗氧化作用。它可以调节 Akt/mTOR 通路，减少肝和胰腺损伤。它可以单独或与二甲双胍联合用于糖尿病的治疗。
