Rathee Neeraj Kumar, Gupta Nidhi, Sharma Sawant, Rathee Hari Krishan
Department of Radiation Oncology, Government Medical College and Hospital, Sector-32, Chandigarh, India.
Department of General Surgery, All India Institute of Medical Sciences, New Delhi, India.
Nepal J Epidemiol. 2022 Mar 31;12(1):1163-1170. doi: 10.3126/nje.v12i1.42975. eCollection 2022 Mar.
Non-Hodgkin's lymphoma of breast is a rare condition. NHL breast constitute about 0.5% of all malignancies of breast. NHL breast constitute nearly 1% of all cases of NHL. Among all subtypes of NHL, DLBCL (Diffuse large B-cell Lymphoma) is the most common type to be known. Marginal zone lymphoma (10-30%), follicular lymphoma (10-20%) and Burkit Lymphoma (5%) are other common histologic variants. Burkitt lymphoma is mainly seen in pregnant females or lactating females. Breast implant associated anapaestic large cell lymphoma (BIA-ALCL) constitutes remaining case. Thus, primary NHL of Breast is rare condition. DLBCL is most common histologic variant. We report here a rare case of primary NHL Breast. A 30 years old lactating mother came with history of swelling and nipple discharge from bilateral breast. -Treatment approach for low grade NHL breast is Radiotherapy only and for high grade NHL breast there is a role for combined modality approach that is chemotherapy followed by Radiotherapy with or without surgical intervention.
乳腺非霍奇金淋巴瘤是一种罕见疾病。乳腺非霍奇金淋巴瘤约占所有乳腺恶性肿瘤的0.5%。乳腺非霍奇金淋巴瘤约占所有非霍奇金淋巴瘤病例的1%。在非霍奇金淋巴瘤的所有亚型中，弥漫性大B细胞淋巴瘤（DLBCL）是最常见的已知类型。边缘区淋巴瘤（10 - 30%）、滤泡性淋巴瘤（10 - 20%）和伯基特淋巴瘤（5%）是其他常见的组织学变异类型。伯基特淋巴瘤主要见于怀孕女性或哺乳期女性。乳房植入物相关间变性大细胞淋巴瘤（BIA - ALCL）构成其余病例。因此，原发性乳腺非霍奇金淋巴瘤是一种罕见疾病。弥漫性大B细胞淋巴瘤是最常见的组织学变异类型。我们在此报告一例罕见的原发性乳腺非霍奇金淋巴瘤病例。一位30岁的哺乳期母亲因双侧乳房肿胀和乳头溢液前来就诊。——低度乳腺非霍奇金淋巴瘤的治疗方法仅为放疗，而高度乳腺非霍奇金淋巴瘤则采用综合治疗方法，即化疗后进行放疗，可伴有或不伴有手术干预。
