Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004 Hunan, China.
Oxid Med Cell Longev. 2022 Apr 27;2022:1059257. doi: 10.1155/2022/1059257. eCollection 2022.
When cells undergo large-scale senescence, organ aging ensues, resulting in irreversible organ pathology and organismal aging. The study of senescence in cells provides an important avenue to understand the factors that influence aging and can be used as one of the useful tools for examining age-related human diseases. At present, many herbal compounds have shown effects on delaying cell senescence. This review summarizes the main characteristics and mechanisms of cell senescence, age-related diseases, and the recent progress on the natural products targeting cellular senescence, with the aim of providing insights to aid the clinical management of age-related diseases.
当细胞发生大规模衰老时，器官老化随之而来，导致不可逆转的器官病理和机体老化。研究细胞衰老为了解影响衰老的因素提供了一个重要途径，也可作为研究与年龄相关的人类疾病的有用工具之一。目前，许多草药化合物已显示出延缓细胞衰老的作用。本文综述了细胞衰老、与年龄相关的疾病的主要特征和机制，以及针对细胞衰老的天然产物的最新进展，旨在为辅助与年龄相关的疾病的临床治疗提供思路。
