Abhilash Mavinakere Ramesh, Gangadhar Akshatha, Krishnegowda Jagadish, Chikkamadaiah Mahendra, Srikantaswamy Shivanna
Department of Studies in Environmental Science, University of Mysore Manasagangotri Mysore 570006 India
Centre for Materials Science and Technology, Vijnana Bhavan, University of Mysore Manasagangotri Mysore 570006 India.
RSC Adv. 2019 Aug 13;9(43):25158-25169. doi: 10.1039/c9ra04978a. eCollection 2019 Aug 8.
The present investigation focuses on the synthesis of metal oxide nanoparticles (MONPs) a facile hydrothermal route. The material has been characterized by using X-ray diffractometry (XRD), X-ray fluorescence (XRF), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), high resolution transmission electron microscopy (HR-TEM), energy dispersive spectroscopy (EDS), photoluminescence (PL), atomic force microscopy (AFM) and Brunauer-Emmett-Teller (BET) techniques. However, the application of FeO metal oxide nanoparticles (MONPs) tied with their inimitable chemical and physical nature is thought to emphasize their exploitable medical and biological applications nowadays. Rhodamine-B (RB) was used for photocatalytic degradation studies by using rhombohedral FeO, afterwards the material was recycled and utilized for toxicity assessments. Undeniably, a meticulous assessment is needed of the factors that influence the biocompatibility and is essential for the safe and sustainable development of the emerging chemically synthesized metal oxide nanoparticle (MONPs). The toxicity assessment of FeO is necessary to know the bioaccumulation and local or systemic toxicity associated to them. The aim of the present study is to investigate the effects of FeO and its histological alterations of the heart tissue of albino Wistar rat. The synthesized materials high dose was found to be highly stable and we found more toxicity against the skin melanoma cells (B16-F10), human embryonic kidney (HEK), 293 cells depending on dose. Finally, , (MTCC 7410) bacterial cell wall damage studies were also conducted to provide a clear determination of rhombohedral nanomaterial behaviour. The fusion of these biocompatibility investigations paves a way for further applications in utilization of these materials in future eco-friendly applications.
本研究聚焦于通过简便的水热法合成金属氧化物纳米颗粒（MONPs）。该材料已通过X射线衍射仪（XRD）、X射线荧光光谱仪（XRF）、傅里叶变换红外光谱仪（FTIR）、动态光散射仪（DLS）、高分辨率透射电子显微镜（HR-TEM）、能量色散光谱仪（EDS）、光致发光光谱仪（PL）、原子力显微镜（AFM）和布鲁诺尔-埃米特-泰勒（BET）技术进行了表征。然而，鉴于FeO金属氧化物纳米颗粒（MONPs）独特的化学和物理性质，其应用被认为在当今具有可开发的医学和生物学应用前景。通过使用菱面体FeO对罗丹明-B（RB）进行光催化降解研究，之后将该材料回收并用于毒性评估。不可否认，需要对影响生物相容性的因素进行细致评估，这对于新兴的化学合成金属氧化物纳米颗粒（MONPs）的安全和可持续发展至关重要。对FeO进行毒性评估，以了解与其相关的生物蓄积以及局部或全身毒性。本研究的目的是调查FeO对白化Wistar大鼠心脏组织的影响及其组织学改变。发现合成材料的高剂量具有高度稳定性，并且我们发现其对皮肤黑色素瘤细胞（B16-F10）、人胚肾（HEK）293细胞的毒性取决于剂量。最后，还进行了（MTCC 7410）细菌细胞壁损伤研究，以明确确定菱面体纳米材料的行为。这些生物相容性研究的融合为这些材料在未来环保应用中的进一步利用铺平了道路。
