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直接C(sp) -H键叠氮化的方法。

Methods for direct C(sp)-H bonds azidation.

作者信息

Liu Ying, Ebadi Abdol Ghaffar, Youseftabar-Miri Leila, Hassanpour Akbar, Vessally Esmail

机构信息

College of Science, North China University of Science and Technology Tangshan 063210 China.

Department of Agriculture, Jouybar Branch, Islamic Azad University Jouybar Iran.

出版信息

RSC Adv. 2019 Aug 13;9(43):25199-25215. doi: 10.1039/c9ra04534a. eCollection 2019 Aug 8.

DOI:10.1039/c9ra04534a
PMID:35528700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069887/
Abstract

Direct functionalization of C-H bonds has attracted great attention in recent years from the perspectives of atom and step economy. In this context, a variety of processes have been developed for the construction of synthetically and biologically important organic azides through the oxidative C-H bonds azidation. In this review, we have summarized recent progress in the direct azidation of C(sp)-H bonds. The review is divided into three major sections: (i) direct azidation of aromatic C-H bonds; (ii) direct azidation of olefinic C-H bonds; and (iii) direct azidation of aldehydic C-H bonds. Mechanistic aspects of the reactions are considered and discussed in detail.

摘要

近年来，从原子经济性和步骤经济性的角度来看，C-H键的直接官能团化引起了极大的关注。在此背景下，已经开发了多种通过氧化C-H键叠氮化来构建具有合成和生物学重要性的有机叠氮化物的方法。在本综述中，我们总结了C(sp)-H键直接叠氮化的最新进展。该综述分为三个主要部分：(i) 芳族C-H键的直接叠氮化；(ii) 烯烃C-H键的直接叠氮化；以及(iii) 醛基C-H键的直接叠氮化。对反应的机理方面进行了详细的考虑和讨论。

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