School of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Iran.
Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.
Top Curr Chem (Cham). 2018 Oct 10;376(6):39. doi: 10.1007/s41061-018-0217-0.
Carbon-sulfur bond formation represents a key step in the synthesis of thioethers, which are a common structural motif in many pharmaceutically compounds. The direct cross-dehydrogenative coupling of C-H/S-H bonds has become a powerful tool for C-S bond formation. As these coupling reactions avoid pre-functionalization of the starting materials, they are more atom-economical, practical, and environmentally friendly than traditional cross-coupling reactions. In this review, we will highlight the most important developments in this novel and interesting research arena with the emphasis on the mechanistic aspects of the reactions. The review is divided into three major sections: (1) C(sp)-H/S-H bonds coupling reactions; (2) C(sp)-H/S-H bonds coupling reactions; and (3) C(sp)-H/S-H bonds coupling reactions.
碳硫键的形成是合成硫醚的关键步骤，硫醚是许多药物化合物中的常见结构基序。C-H/S-H 键的直接交叉脱氢偶联已成为 C-S 键形成的有力工具。由于这些偶联反应避免了起始材料的预官能化，因此它们比传统的交叉偶联反应更具原子经济性、实用性和环境友好性。在这篇综述中，我们将重点介绍该新颖而有趣的研究领域中的最重要进展，并强调反应的机理方面。综述分为三个主要部分：（1）C(sp)-H/S-H 键偶联反应；（2）C(sp)-H/S-H 键偶联反应；和（3）C(sp)-H/S-H 键偶联反应。
