Kim Juntae, Yang Pil-Sung, Park Byoung-Eun, Kang Tae Soo, Lim Seong-Hoon, Cho Sungsoo, Lee Su-Yeon, Chung Young Hak, Lee Myung-Yong, Kim Dongmin, Joung Boyoung
Division of Cardiology, Department of Internal Medicine, College of Medicine, Dankook University, Cheonan-si, South Korea.
Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam-si, South Korea.
Front Cardiovasc Med. 2022 Apr 22;9:859277. doi: 10.3389/fcvm.2022.859277. eCollection 2022.
There is a paucity of information about mortality related to light-intensity physical activity (LPA) in the older population. We examine the associations between physical activity and mortality, focusing on the effect of light-intensity physical activity and the dose-response relationship between physical activity and mortality.
We analyzed a total of 58,537 participants aged ≥ 65 years (mean age, 73.9 ± 5.8 years; male, 36.0%) in the Korean National Health Insurance Service database between 2009 and 2012. The Date of the end of follow-up was December 31, 2013. Individuals were divided into four categories according to physical activity intensity: totally sedentary (43.3%), LPA only (35.8%), LPA and moderate- to vigorous-intensity physical activity (MVPA) (16.3%), MVPA only (4.5%). Physical activity was quantified using standardized self-reported questionnaires which composed of the duration and frequency of physical activity.
During a mean follow-up of 39.6 ± 14.0 months, 5,651 (9.7%) deaths occurred. Compared with totally sedentary individuals, those in the LPA only, LPA and MVPA, and MVPA only groups showed 26% [hazard ratio (HR) 0.74, 95% confidence interval (CI) 0.68-0.82], 27% (HR 0.73, 95% CI 0.63-0.84), and 34% (HR 0.66, 95% CI 0.54-0.79) lower all-cause mortality risk, showing an inverse relationship between physical activity intensity and mortality risk. In contrast, the LPA only, LPA and MVPA, and MVPA only groups represented a stronger inverse association with CV mortality (LPA: HR 0.76, 95% CI 0.62-0.92; LPA with MVPA: HR 0.74, 95% CI 0.55-0.999; MVPA, HR 0.57, 95% CI 0.37-0.87). Among participants performing LPA alone, participants performing less than the recommended dose of physical activity had lower all-cause mortality than those with sedentary activity (1-249 MET-min/week: HR 0.74, 95% CI 0.67-0.82, 250-499 MET-min/week: HR 0.65, 95% CI 0.59-0.72).
Physical activity, even low doses of LPA, was associated with reduced mortality risk in the elderly population. This study may motivate sedentary individuals to engage in any physical activity for mortality benefits.
关于老年人群中与轻度体力活动（LPA）相关的死亡率信息匮乏。我们研究体力活动与死亡率之间的关联，重点关注轻度体力活动的影响以及体力活动与死亡率之间的剂量反应关系。
我们分析了2009年至2012年韩国国民健康保险服务数据库中总共58537名年龄≥65岁的参与者（平均年龄73.9±5.8岁；男性占36.0%）。随访结束日期为2013年12月31日。根据体力活动强度将个体分为四类：完全久坐不动（43.3%）、仅进行轻度体力活动（35.8%）、轻度体力活动与中度至剧烈体力活动（MVPA）（16.3%）、仅进行中度至剧烈体力活动（4.5%）。使用由体力活动的持续时间和频率组成的标准化自我报告问卷对体力活动进行量化。
在平均39.6±14.0个月的随访期间，发生了5651例（9.7%）死亡。与完全久坐不动的个体相比，仅进行轻度体力活动、轻度体力活动与中度至剧烈体力活动以及仅进行中度至剧烈体力活动组的全因死亡风险分别降低了26%[风险比（HR）0.74，95%置信区间（CI）0.68 - 0.82]、27%（HR 0.73，95% CI 0.63 - 0.84）和34%（HR 0.66，95% CI 0.54 - 0.79），表明体力活动强度与死亡风险呈负相关。相比之下，仅进行轻度体力活动、轻度体力活动与中度至剧烈体力活动以及仅进行中度至剧烈体力活动组与心血管疾病死亡率的负相关更强（轻度体力活动：HR 0.76，95% CI 0.62 - 0.92；轻度体力活动与中度至剧烈体力活动：HR 0.74，95% CI 0.55 - 0.999；中度至剧烈体力活动，HR 0.57，95% CI 0.37 - 0.87）。在仅进行轻度体力活动的参与者中，体力活动量低于推荐剂量的参与者全因死亡率低于久坐不动的参与者（每周1 - 249代谢当量分钟：HR 0.74，95% CI 0.67 - 0.82，每周250 - 499代谢当量分钟：HR 0.65，95% CI 0.59 - 0.72）。
体力活动，即使是低剂量的轻度体力活动，也与老年人群死亡率风险降低相关。本研究可能会促使久坐不动的个体为了降低死亡风险而参与任何体力活动。
