ChAdOx1 nCoV-19疫苗接种后急性暴发性心肌炎：一例报告及文献综述
Acute Fulminant Myocarditis After ChAdOx1 nCoV-19 Vaccine: A Case Report and Literature Review.
作者信息
Wu Chia-Tung, Chin Shy-Chyi, Chu Pao-Hsien
机构信息
Department of Cardiology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan City, Taiwan.
出版信息
Front Cardiovasc Med. 2022 Apr 21;9:856991. doi: 10.3389/fcvm.2022.856991. eCollection 2022.
According to recent literatures, myocarditis is an uncommon side effect of mRNA vaccines against COVID-19. On the other hand, myocarditis after adenovirus based vaccine is rarely reported. Here we report a middle-aged healthy female who had acute fulminant perimyocarditis onset 2 days after the first dose of ChAdOx1 vaccine (AstraZeneca) without any other identified etiology. Detailed clinical presentation, serial ECGs, cardiac MRI, and laboratory data were included in the report. Possible mechanisms of acute myocarditis after adenoviral vaccine was reviewed and discussed. To our knowledge, a few cases of myocarditis after Ad26.COV2.S vaccine were reported, and this is the first case report after ChAdOx1 vaccine.
根据最近的文献，心肌炎是新型冠状病毒肺炎mRNA疫苗罕见的副作用。另一方面，基于腺病毒的疫苗接种后发生心肌炎的报道很少。在此，我们报告一名中年健康女性，在接种第一剂ChAdOx1疫苗（阿斯利康）2天后出现急性暴发性心包心肌炎，无其他明确病因。报告中包括详细的临床表现、系列心电图、心脏磁共振成像和实验室数据。对腺病毒疫苗接种后急性心肌炎的可能机制进行了回顾和讨论。据我们所知，有几例Ad26.COV2.S疫苗接种后发生心肌炎的病例报告，而这是ChAdOx1疫苗接种后首例病例报告。
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