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芳烃和烯烃与炔基硅烷的共催化-C-H官能化/环化反应：通向异喹啉酮和吡啶酮结构单元的途径

Co-catalyzed -C-H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs.

作者信息

Lin Cong, Shen Liang

机构信息

College of Chemistry and Chemical Engineering, Jiangxi Science & Technology Normal University Nanchang 330013 China

Jiangxi Engineering Laboratory of Waterborne Coatings, College of Chemistry and Chemical Engineering, Jiangxi Science & Technology Normal University Nanchang 330013 China.

出版信息

RSC Adv. 2019 Sep 26;9(53):30650-30654. doi: 10.1039/c9ra06963a.

DOI:10.1039/c9ra06963a
PMID:35529370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072155/
Abstract

A method for cobalt-catalyzed -C-H functionalization annulation of arenes and alkenes with alkynylsilanes assisted by 8-aminoquinolyl auxiliary has been described. Alkynylsilanes were employed as the coupling partners to react with a broad range of benzamides and acrylamides, affording the corresponding isoquinolone and pyridone derivatives in moderate to high yields. It is worth noting that the silyl group in the final products can be retained or removed by switching the reaction conditions.

摘要

描述了一种在8-氨基喹啉辅助下，钴催化芳烃和烯烃与炔基硅烷进行-C-H官能化环化的方法。炔基硅烷被用作偶联伙伴，与多种苯甲酰胺和丙烯酰胺反应，以中等至高产率得到相应的异喹啉酮和吡啶酮衍生物。值得注意的是，通过改变反应条件，最终产物中的硅烷基可以保留或去除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/f883444c1c83/c9ra06963a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/52cc4f70ba52/c9ra06963a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/c31af476c403/c9ra06963a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/f6be87ef6eed/c9ra06963a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/f883444c1c83/c9ra06963a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/52cc4f70ba52/c9ra06963a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/c31af476c403/c9ra06963a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/f6be87ef6eed/c9ra06963a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e998/9072155/f883444c1c83/c9ra06963a-s4.jpg

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