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钯催化脱氢环化法高效合成菲啶酮

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones.

作者信息

Li Xinyao, Pan Jun, Song Song, Jiao Ning

机构信息

State Key Laboratory of Natural and Biomimetic Drugs , School of Pharmaceutical Sciences , Peking University , Xue Yuan Rd. 38 , Beijing 100191 , China . Email:

State Key Laboratory of Elemento-organic Chemistry , Nankai University , Weijin Rd. 94 , Tianjin 300071 , China.

出版信息

Chem Sci. 2016 Aug 1;7(8):5384-5389. doi: 10.1039/c6sc01148a. Epub 2016 Apr 26.

DOI:10.1039/c6sc01148a
PMID:30155191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6020758/
Abstract

A novel Pd-catalyzed intermolecular dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed. Simple aryl iodides and carbamic chlorides readily made from various anilines, a broad substrate scope with hetero/polycycles, as well as high-value products, make this direct dehydrogenative annulation approach very practical and attractive.

摘要

开发了一种新颖的钯催化芳基碘化物与芳基氨基甲酰氯的分子间脱氢环化反应，用于高效合成菲啶酮衍生物。由各种苯胺容易制得的简单芳基碘化物和氨基甲酰氯、具有杂环/多环的广泛底物范围以及高价值产物，使得这种直接脱氢环化方法非常实用且具有吸引力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/0cdaee78aab7/c6sc01148a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/0e89a39b3388/c6sc01148a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/613a6f9b1e0f/c6sc01148a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/55cef2e58f41/c6sc01148a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/0cdaee78aab7/c6sc01148a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/0e89a39b3388/c6sc01148a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/613a6f9b1e0f/c6sc01148a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/55cef2e58f41/c6sc01148a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/6020758/0cdaee78aab7/c6sc01148a-f2.jpg

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Palladium-Catalyzed Catellani ortho-Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones.
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