Yang Runlin, Li Yaoqi, Wang Xinyu, Yan Junjie, Pan Donghui, Xu Yuping, Wang Lizhen, Yang Min
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine Wuxi 214063 China
RSC Adv. 2019 Sep 10;9(49):28548-28553. doi: 10.1039/c9ra04478g. eCollection 2019 Sep 9.
In recent years, ferroptosis has been investigated widely as a new form of cell death. Development of nanodrugs for ferroptosis induction in cancer cells may be a promising approach for cancer treatment. Here, we developed a type of nanoparticle consisting of the antitumor drug doxorubicin and exogenous ferritin. The drug loading process did not change the size of ferritin obviously. And this nanoparticle could induce the accumulation of ROS and cell ferroptosis for transferrin receptor overexpressed tumor cell, HT29. The ferroptosis process was also confirmed using inhibitors for ferroptosis. The cytotoxicity of this nanoparticle is similar to that of free DOX. This study provides a new strategy for targeting and killing transferrin receptor overexpressed tumor cells.
近年来，铁死亡作为一种新的细胞死亡形式受到了广泛研究。开发用于诱导癌细胞铁死亡的纳米药物可能是一种有前景的癌症治疗方法。在此，我们开发了一种由抗肿瘤药物阿霉素和外源性铁蛋白组成的纳米颗粒。药物装载过程并未明显改变铁蛋白的大小。并且这种纳米颗粒能够诱导活性氧的积累以及转铁蛋白受体过表达的肿瘤细胞HT29发生铁死亡。使用铁死亡抑制剂也证实了铁死亡过程。这种纳米颗粒的细胞毒性与游离阿霉素相似。本研究为靶向杀伤转铁蛋白受体过表达的肿瘤细胞提供了一种新策略。
