甲萘醌：一种用于合成有价值化合物的平台和目标。

Menadione: a platform and a target to valuable compounds synthesis.

作者信息

de Souza Acácio S, Ribeiro Ruan Carlos B, Costa Dora C S, Pauli Fernanda P, Pinho David R, de Moraes Matheus G, da Silva Fernando de C, Forezi Luana da S M, Ferreira Vitor F

机构信息

Universidade Federal Fluminense, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, R. Dr. Mario Vianna, 523, Santa Rosa, CEP 24241-002, Niterói-RJ, Brazil.

Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.

出版信息

Beilstein J Org Chem. 2022 Apr 11;18:381-419. doi: 10.3762/bjoc.18.43. eCollection 2022.

Naphthoquinones are important natural or synthetic compounds belonging to the general class of quinones. Many compounds in this class have become drugs that are on the pharmaceutical market for the treatment of various diseases. A special naphthoquinone derivative is menadione, a synthetic naphthoquinone belonging to the vitamin K group. This compound can be synthesized by different methods and it has a broad range of biological and synthetic applications, which will be highlighted in this review.