Wei Tianyue, Wang Jin, Yu Xunzhi, Wang Youfa, Wu Qingzhi, Chen Chang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology Wuhan 430070 China
Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology Wuhan 430070 China.
RSC Adv. 2019 Oct 28;9(59):34642-34651. doi: 10.1039/c9ra05258e. eCollection 2019 Oct 23.
Weak mechanical properties and mismatching of elastic modulus to human bone restricts the use of PEEK as a bone implant material. By introducing reinforcing particles in polymers, composite material properties could be tailored to meet specific design requirements. In this work, composite materials with PEEK as a matrix and AlO as reinforcing fillers were prepared by an injection molding method. Subsequently, the effects of different particle sizes (30 nm, 0.2 μm, 5 μm) and distinct contents (2.5 wt%, 5.0 wt%, 7.5 wt%, 10.0 wt%, 12.5 wt%, 15.0 wt%) of AlO powder on the mechanical properties of the composites, such as tensile strength, bending strength, impact strength, Vickers hardness and modulus, were investigated by an electronic universal testing machine. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare the thermal properties of composites with different proportions. Besides, the cross-section fractography of the composites after the tensile strength test was characterized by scanning electron microscopy (SEM) to analyze the interface bonding effect. Moreover, mouse fibroblast L929 cells were used for cytotoxicity testing of CCK-8 kit to evaluate cell compatibility of the composite and cell morphology was observed by inverted fluorescence microscopy. Based on the obtained results, AlO reinforcement enhanced many properties in some aspects, which makes the AlO/PEEK composite one of the most promising candidates for human bone implantation, reconstruction, orthopedic and trauma applications.
聚醚醚酮（PEEK）的力学性能较弱且弹性模量与人体骨骼不匹配，限制了其作为骨植入材料的应用。通过在聚合物中引入增强颗粒，可以调整复合材料的性能以满足特定的设计要求。在本研究中，采用注射成型法制备了以PEEK为基体、AlO为增强填料的复合材料。随后，利用电子万能试验机研究了不同粒径（30 nm、0.2 μm、5 μm）和不同含量（2.5 wt%、5.0 wt%、7.5 wt%、10.0 wt%、12.5 wt%、15.0 wt%）的AlO粉末对复合材料力学性能（如拉伸强度、弯曲强度、冲击强度、维氏硬度和模量）的影响。采用热重分析（TGA）和差示扫描量热法（DSC）比较了不同比例复合材料的热性能。此外，通过扫描电子显微镜（SEM）对拉伸强度测试后的复合材料横截面断口进行表征，以分析界面结合效果。此外，使用小鼠成纤维细胞L929进行CCK-8试剂盒的细胞毒性测试，以评估复合材料的细胞相容性，并通过倒置荧光显微镜观察细胞形态。基于所得结果，AlO增强在某些方面提高了许多性能，这使得AlO/PEEK复合材料成为人体骨植入、重建、骨科和创伤应用中最有前景的候选材料之一。
