Xiao Feng, Fan Jialong, Tong Chunyi, Xiao Chang, Wang Zhou, Liu Bin, Daniyal Muhammad, Wang Wei
College of Biology, Hunan University Changsha 410082 China
TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208 P. R. China
RSC Adv. 2019 Sep 4;9(48):27911-27926. doi: 10.1039/c9ra05867b. eCollection 2019 Sep 3.
The tumor variability and low efficiency associated with conventional chemical drugs provide an impetus to develop drug-carrying systems with targeted accumulation and controllable release behavior. Herein, DOX-loaded Prussian blue (PB) nano-composites are developed after coating with erythrocyte membrane (EM) and modifying with folic acid (FA). In these nano-composites, PB nanoparticles mixture with different shapes were adopted to improve the photothermal performance, which is highly helpful for cancer photothermal ablation and controllable drug release. In addition, the nano-composites were endowed with high biocompatibility, immune evading capacity, pH-/photo-responsive release behavior, and markedly prolonged blood circulation time, which was reflected by a 99.6% cervical tumor growth inhibition value (TGI) . Meanwhile, they functioned as multimodal bioimaging agents for photothermal, fluorescence, and photoacoustic imaging of tumors. The reported strategy can be applied for personalized therapy of various tumors by modifying the tumor-targeting molecule on the surface of nanoparticles.
传统化学药物所具有的肿瘤变异性和低效率推动了具有靶向积累和可控释放行为的载药系统的开发。在此，负载阿霉素的普鲁士蓝（PB）纳米复合材料是在包覆红细胞膜（EM）并用叶酸（FA）修饰后制备而成。在这些纳米复合材料中，采用了不同形状的PB纳米颗粒混合物来提高光热性能，这对癌症光热消融和可控药物释放非常有帮助。此外，这些纳米复合材料具有高生物相容性、免疫逃避能力、pH/光响应释放行为以及显著延长的血液循环时间，这体现在99.6%的宫颈癌生长抑制值（TGI）上。同时，它们还作为多模态生物成像剂用于肿瘤的光热、荧光和光声成像。所报道的策略可通过在纳米颗粒表面修饰肿瘤靶向分子应用于各种肿瘤的个性化治疗。
