Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shanghai Key Laboratory of Gynecologic Oncology, Shanghai, China.
Clin Transl Med. 2021 Feb;11(2):e292. doi: 10.1002/ctm2.292.
In recent years, cell membrane camouflaging technology has emerged as an important strategy of nanomedicine, and the modification on the membranes is also a promising approach to enhance the properties of the nanoparticles, such as cancer targeting, immune evasion, and phototherapy sensitivity. Indeed, diversified approaches have been exploited to re-engineer the membranes of nanoparticles in several studies. In this review, first we discuss direct modification strategy of cell membrane camouflaged nanoparticles (CM-NP) via noncovalent, covalent, and enzyme-involved methods. Second, we explore how the membranes of CM-NPs can be re-engineered at the cellular level using strategies such as genetic engineering and membranes fusion. Due to the innate biological properties and excellent biocompatibility, the functionalized cell membrane-camouflaged nanoparticles have been widely applied in the fields of drug delivery, imaging, detoxification, detection, and photoactivatable therapy.
近年来，细胞膜伪装技术已经成为纳米医学的重要策略，对细胞膜的修饰也是增强纳米粒子性能的一种有前途的方法，如癌症靶向、免疫逃逸和光疗敏感性。事实上，在几项研究中，已经开发了多种方法来重新设计纳米粒子的细胞膜。在这篇综述中，首先我们讨论了通过非共价、共价和酶参与的方法对细胞膜伪装纳米粒子（CM-NP）进行直接修饰的策略。其次，我们探讨了如何使用基因工程和膜融合等策略在细胞水平上重新设计 CM-NP 的膜。由于具有固有生物特性和优异的生物相容性，功能化细胞膜伪装纳米粒子已广泛应用于药物输送、成像、解毒、检测和光活化治疗等领域。
