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转录因子EB（TFEB）的研究热点与趋势分析：文献计量学与科学计量学分析

Research Hotspots and Trends Analysis of TFEB: A Bibliometric and Scientometric Analysis.

作者信息

Zhou Runjin, Lin Xiaoling, Liu Dongmin, Li Zhao, Zeng Jingchun, Lin Xingdong, Liang Xiaodi

机构信息

Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.

The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Front Mol Neurosci. 2022 Apr 21;15:854954. doi: 10.3389/fnmol.2022.854954. eCollection 2022.

DOI:10.3389/fnmol.2022.854954
PMID:35531069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069162/
Abstract

OBJECTIVE

To explore the development context, research hotspots and frontiers of Transcription factor EB (TFEB) from 1991 to 2021 by bibliometric analysis.

METHODS

Publications about TFEB research from 1991 to 2021 were retrieved from the Web of Science Core Collection (WoSCC). Excel 2007 was used to collect basic information, including publications, research areas. VOSviewer 1.6.17 was used to analyze co-authorship of countries, institutes and authors. Co-citation of cited authors, cited references were analyzed by CiteSpace V.5.8.R3. In addition, CiteSpace was used to analyze keywords cluster and forecast research frontiers.

RESULTS

A total of 1,059 literatures were retrieved, including 1,340 research institutes and 393 academic journals. The main area of research related to TFEB is biology (340), the most published country and institutes were the United States (487) and Baylor College of Medicine (70). Settembre C owned the highest co-citations (663). Trending keywords may indicate frontier topics, including "Alzheimer's disease," "Parkinson's disease," "(p21; q12)," "melanoma," "pancreatic cancer," "breast cancer," "calcineurin," "TFE3," "trehalose," and "curcumin."

CONCLUSION

This research provides valuable information for the study of TFEB. Disease research focuses more on neurodegenerative diseases (NDs) and tumors. Trehalose and curcumin are novel agents acting on TFEB. Rap-TRPML1-Calcineurin-TFEB and TFE3 are increasing signal pathway researches, similarly, the molecular biological mechanism of TFEB needs further exploration.

摘要

目的

通过文献计量分析，探讨1991年至2021年转录因子EB（TFEB）的发展脉络、研究热点及前沿。

方法

从Web of Science核心合集（WoSCC）中检索1991年至2021年关于TFEB研究的出版物。使用Excel 2007收集基本信息，包括出版物、研究领域等。运用VOSviewer 1.6.17分析国家、机构和作者的合作情况。通过CiteSpace V.5.8.R3分析被引作者、被引参考文献的共被引情况。此外，利用CiteSpace分析关键词聚类并预测研究前沿。

结果

共检索到1059篇文献，涉及1340个研究机构和393种学术期刊。与TFEB相关的主要研究领域是生物学（340），发表文献最多的国家和机构分别是美国（487）和贝勒医学院（70）。Settembre C的共被引次数最高（663）。趋势关键词可能预示前沿主题，包括“阿尔茨海默病”“帕金森病”“（p21；q12）”“黑色素瘤”“胰腺癌”“乳腺癌”“钙调神经磷酸酶”“TFE3”“海藻糖”和“姜黄素”。

结论

本研究为TFEB的研究提供了有价值的信息。疾病研究更多地集中在神经退行性疾病（NDs）和肿瘤方面。海藻糖和姜黄素是作用于TFEB的新型药物。Rap-TRPML1-钙调神经磷酸酶-TFEB和TFE3的信号通路研究日益增多，同样，TFEB的分子生物学机制有待进一步探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/924c4eddc310/fnmol-15-854954-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/4a1cebde1236/fnmol-15-854954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/c2f936b4eb5f/fnmol-15-854954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/b3bd0be632a2/fnmol-15-854954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/0ba70774f876/fnmol-15-854954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/0faefb067513/fnmol-15-854954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/f5bde6a35d69/fnmol-15-854954-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/924c4eddc310/fnmol-15-854954-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/4a1cebde1236/fnmol-15-854954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/c2f936b4eb5f/fnmol-15-854954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/b3bd0be632a2/fnmol-15-854954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/0ba70774f876/fnmol-15-854954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/0faefb067513/fnmol-15-854954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/f5bde6a35d69/fnmol-15-854954-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d77/9069162/924c4eddc310/fnmol-15-854954-g007.jpg

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Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response.海藻糖会引起低水平的溶酶体应激，从而激活 TFEB 和自噬溶酶体生物发生反应。
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