Richardson T C, Humm S A, Carr T E
Histochemistry. 1987;86(4):437-9. doi: 10.1007/BF00495007.
A monoclonal antibody (RBU/01) was raised against human thyroglobulin and its suitability for the immunohistochemical staining of thyroglobulin was determined on fixed, wax-embedded tissue, using the peroxidase anti-peroxidase (PAP) method. The antibody was then used to demonstrate the expression of human thyroglobulin in sections of a human follicular carcinoma of the thyroid which had been grown in immunodeficient mice. It is concluded that the immunohistochemical evaluation of the xenografts with the antibody provides useful information on this xenograft system as a potential model for thyroid carcinoma.
制备了一种抗人甲状腺球蛋白的单克隆抗体（RBU/01），并采用过氧化物酶抗过氧化物酶（PAP）法，在固定的石蜡包埋组织上确定了该抗体用于甲状腺球蛋白免疫组织化学染色的适用性。然后，使用该抗体来检测在免疫缺陷小鼠体内生长的人甲状腺滤泡癌切片中人甲状腺球蛋白的表达。得出的结论是，用该抗体对异种移植瘤进行免疫组织化学评估，可为作为甲状腺癌潜在模型的该异种移植系统提供有用信息。
