Kheder Alatawi Saleha, Alyahyawi Hanan E, Akhter Naseem, Alharbi Raed A, Am Ahmed Waled, Saleh R Almalki Shaia
Department of Optometry, Faculty of Applied Medical Sciences, Albaha University, Saudi Arabia.
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Saudi Arabia.
Saudi J Biol Sci. 2022 Apr;29(4):2026-2032. doi: 10.1016/j.sjbs.2021.12.053. Epub 2021 Dec 29.
Although Human Adenoviruses outbreaks are rare, there still could be a potential chance for those viruses to mutate and spread quickly in human populations with severe public health and socioeconomic consequences. Outbreaks often spread fairly quickly with considerable morbidity/mortality. Saudi Arabia's geopolitical and religious significance bring with it, millions of pilgrims, and tourists yearly. This presents a significant potential for HAdVs epidemics. This review shows that even with the mushrooming serotypes and genotypes, the scholarly knowledge on the nature, structure, transmission, and management of HAdVs is already well-established. Significant research is ongoing on pharmacological interventions, which, presently remain speculative and lacking in effectiveness. This review similarly uncovers a shortage of literature, both recent and dated, on epidemic keratoconjunctivitis in either Saudi Arabia or the Middle East.
尽管人类腺病毒爆发很少见,但这些病毒仍有可能发生变异并在人群中迅速传播,从而带来严重的公共卫生和社会经济后果。疫情通常传播相当迅速,发病率/死亡率较高。沙特阿拉伯的地缘政治和宗教意义每年吸引数百万朝圣者和游客。这为人类腺病毒流行带来了巨大的潜在风险。本综述表明,即使人类腺病毒的血清型和基因型不断增加,关于其性质、结构、传播和管理的学术知识已经相当完善。目前正在进行大量关于药物干预的研究,但目前这些研究仍具有推测性且缺乏有效性。同样,本综述发现,关于沙特阿拉伯或中东地区流行性角结膜炎的近期和过时文献都很匮乏。