Chartrand S A, Scribner R K, Marks M I, Dice J
J Antimicrob Chemother. 1987 Feb;19(2):221-4. doi: 10.1093/jac/19.2.221.
Mean peak enoxacin serum concentrations in nonfasted CF-1 mice following a single 50, 100, or 200 mg/kg oral dose were 2.0, 4.0 and 11.4 mg/l, respectively, with proportional increases in area under the serum concentration curves. Oral enoxacin was significantly more effective than tobramycin or dicloxacillin in experimental Pseudomonas aeruginosa and Staphylococcus aureus infections respectively. Enoxacin was as effective as tobramycin against P. cepacia and Escherichia coli infections. Enoxacin may be useful as an oral antimicrobial for the treatment of selected systemic bacterial infections.
在非禁食的CF - 1小鼠中，单次口服50、100或200mg/kg剂量的依诺沙星后，平均血清峰值浓度分别为2.0、4.0和11.4mg/l，血清浓度曲线下面积也相应增加。在实验性铜绿假单胞菌和金黄色葡萄球菌感染中，口服依诺沙星分别比妥布霉素或双氯西林显著更有效。在洋葱伯克霍尔德菌和大肠杆菌感染方面，依诺沙星与妥布霉素效果相当。依诺沙星可用作口服抗菌药物治疗某些全身性细菌感染。
