Federspil P J, Lind A, Tiesler E, Schmidt B
Infection. 1986;14 Suppl 3:S211-2. doi: 10.1007/BF01667846.
The efficacy and tolerance of enoxacin were tested in 65 patients treated for ear, nose and throat infections with doses of 400 or 600 mg b.i.d. The overall clinical efficacy of enoxacin was excellent in 32, good in 17, fair in six, and poor in five out of 60 evaluable patients. Three female patients complained of stomach pressure and one man of slight nausea, two of allergic skin reactions and one of arthromyalgia. The pharmacokinetic studies showed high enoxacin concentrations in the secretions, pus, and tissues studied, especially in those of the middle ear and the sinuses.
对65例接受耳鼻喉感染治疗的患者进行了依诺沙星的疗效和耐受性测试，剂量为每日两次，每次400或600毫克。在60例可评估患者中，依诺沙星的总体临床疗效为：32例优秀，17例良好，6例中等，5例较差。3名女性患者抱怨有胃部压迫感，1名男性有轻微恶心，2名有皮肤过敏反应，1名有关节痛。药代动力学研究表明，在所研究的分泌物、脓液和组织中，尤其是中耳和鼻窦的组织中，依诺沙星浓度很高。
